Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling

PloS One
Yu-Chen TsaiGert O Pflugfelder

Abstract

Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.

References

Oct 15, 1976·Developmental Biology·D F ReadyS Benzer
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A KassisN Perrimon
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F de CelisA García-Bellido
Mar 1, 1986·The Journal of Experimental Zoology·J L Haynie, P J Bryant
Mar 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·G O Pflugfelder, M Heisenberg
Apr 1, 1996·Journal of Medical Genetics·R A Newbury-EcobI D Young
Oct 11, 1996·Science·M CallejaG Morata
Aug 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D L ChapmanV E Papaioannou
Jan 1, 1997·Developmental Genetics·F Chanut, U Heberlein
Aug 14, 1999·Mechanisms of Development·N GorfinkielI Guerrero
Aug 26, 1999·Trends in Genetics : TIG·W J Gehring, K Ikeo
Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J E Treisman
Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N M Bonini, M E Fortini
Jul 20, 2002·Seminars in Cell & Developmental Biology·Kenneth M Cadigan
Sep 17, 2002·Genes & Development·Jose BessaRichard S Mann
Nov 7, 2003·Developmental Cell·Andrew Tomlinson

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
transgenic

Software Mentioned

Zeiss Zen 2009

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis