Opuntia Extract Reduces Scar Formation in Rabbit Ear Model: A Randomized Controlled Study

The International Journal of Lower Extremity Wounds
Quan FangShaolin Ma

Abstract

The purpose of this article is to investigate the effect of Opuntia stricta H (Cactaceae) extract on suppression of hypertrophic scar on ventral surface wounds of rabbit ears. Full thickness skin defection was established in a rabbit ear to simulate hypertrophic scar. Opuntia extract was sprayed on the wounds in the experimental group, and normal saline was used in the control group. After the wounds healed with scar formation, the hypertrophic scar tissue was harvested on days 22, 39, and 54 for histological analysis. The expression of type I and type III collagen and matrix metalloproteinase-1 (MMP-1) were evaluated by immunohistochemistry and real-time quantitative polymerase chain reaction. The results indicated that the scar of the control group is more prominent compared with the opuntia extract group. The expression of type I collagen in the opuntia extract group was lower than the control group, while type III collagen in opuntia extract group gradually increased and exceeded control group. The expression of MMP-1 decreased in the opuntia extract group, while the control group increased over time, but the amount of MMP-1 was much higher than that in the control group on day 22. In conclusion, opuntia extract reduces hyp...Continue Reading

References

Sep 1, 1997·Plastic and Reconstructive Surgery·D E MorrisT A Mustoe
May 16, 2000·Plastic and Reconstructive Surgery·J R MarcusT A Mustoe
Jun 28, 2002·Plastic and Reconstructive Surgery·Alexandrina S SaulisThomas A Mustoe
May 14, 2005·Skinmed·Ardeshir Bayat, Duncan Angus McGrouther
Sep 10, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kenneth R Cutroneo
Jul 26, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Andrea A Tandara, Thomas A Mustoe
Dec 20, 2011·Journal of the American Academy of Dermatology·Christos ProfyrisIsabel Do Vale
Jun 8, 2012·ISRN Dermatology·K J Rolfe, A O Grobbelaar
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·David D LoH Peter Lorenz
Feb 11, 2014·BioMed Research International·M M Al-Qattan, T M Al-Kharfy
Apr 29, 2014·Burns : Journal of the International Society for Burn Injuries·Anna I ArnoMarc G Jeschke
Sep 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karym El-MostafaMustapha Cherkaoui-Malki

❮ Previous
Next ❯

Citations

Dec 19, 2015·The International Journal of Lower Extremity Wounds·Kittipan Rerkasem, Raj Mani

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCR
Polymerase Chain

Software Mentioned

Photoshop
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.