Oral β-blockade in relation to energy expenditure in clinically stable patients with liver cirrhosis: a double-blind randomized cross-over trial

Metabolism: Clinical and Experimental
Wai Gin LeeLindsay D Plank

Abstract

Elevated resting energy expenditure (REE) is seen in liver cirrhosis and is associated with reduced transplant-free survival. Non-selective β-blockers reduce REE in acute hypermetabolic conditions. We examined whether non-selective β-blockers reduce REE in patients with stable liver cirrhosis. Twenty-two stable cirrhotic patients (Child-Pugh grading: 19A, 2B, 1C) were randomized to 3-month treatment with nadolol (titrated to decrease resting pulse rate by 20%) or placebo and after a 1-month washout period crossed to the alternative treatment for a further 3 months. REE was measured by indirect calorimetry and total body protein by neutron activation analysis at the beginning and end of each 3-month period of treatment. A predicted REE was calculated for each patient based on total body protein. A measured to predicted REE ratio >1.22 indicated significantly elevated REE. The primary outcome was REE at the end of 3-month treatment with nadolol compared with placebo. Elevated REE was seen in one patient at study entry. After 3 months on placebo REE was 1506±40 (SEM) kcal/d and on nadolol, 1476±40 kcal/d, a mean reduction of 31±16 kcal/d (P=.076). Total body protein changes were not significant. Nadolol was well tolerated with no ...Continue Reading

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References

Jun 1, 1991·Metabolism: Clinical and Experimental·S WelleM Statt
Sep 1, 1985·Controlled Clinical Trials·J L FleissR Rosenfeld
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O SelbergM J Müller
Jun 5, 1999·The American Journal of Clinical Nutrition·M J MüllerM P Manns
Oct 30, 2001·The New England Journal of Medicine·D N HerndonR R Wolfe
Mar 8, 2002·Nutrition·Masahiro TajikaHisataka Moriwaki
Jun 28, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F W GuglielmiA Francavilla
Jun 1, 1994·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M J MüllerR Pichlmayr
May 11, 2007·The American Journal of Clinical Nutrition·Szelin PengEdward J Gane
Jul 16, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lindsay D PlankJohn L McCall
Feb 10, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P LeeK K Y Ho

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Citations

Nov 13, 2015·European Journal of Gastroenterology & Hepatology·César Prieto-FríasJorge Quiroga
Nov 19, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lívia Garcia FerreiraMaria Isabel Toulson Davisson Correia
Jan 16, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Helem S RibeiroMaria Isabel T D Correia
May 1, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Karen Louise ThomsenHendrik Vilstrup
Sep 27, 2016·Diabetes/metabolism Research and Reviews·Wai Gin LeeLindsay D Plank
Jul 25, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cameron I WellsLindsay D Plank

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