PMID: 2125594Nov 1, 1990Paper

Oral [13C]bicarbonate measurement of CO2 stores and dynamics in children and adults

Journal of Applied Physiology
Y ArmonS Epstein

Abstract

During exercise, less additional CO2 is stored per kilogram body weight in children than in adults, suggesting that children have a smaller capacity to store metabolically produced CO2. To examine this, tracer doses of [13C]bicarbonate were administered orally to 10 children (8-12 yr) and 12 adults (25-40 yr) at rest. Washout of 13CO2 in breath was analyzed to estimate recovery of tracer, mean residence time (MRT), and size of CO2 stores. CO2 production (VCO2) was also measured breath by breath using gas exchange techniques. Recovery did not differ significantly between children [73 +/- 13% (SD)] and adults (71 +/- 9%). MRT was shorter in children (42 +/- 7 min) compared with adults (66 +/- 15 min, P less than 0.001). VCO2 per kilogram was higher in the children (5.4 +/- 0.9 ml.min-1.kg-1) compared with adults (3.1 +/- 0.5, P less than 0.0001). Tracer estimate of CO2 production was correlated to VCO2 (r = 0.86, P less than 0.0001) and when corrected for mean recovery accurately predicted the VCO2 to within 3 +/- 14%. There was no difference in the estimate of resting CO2 stores between children (222 +/- 52 ml CO2/kg) and adults (203 +/- 42 ml CO2/kg). We conclude that orally administered [13C]bicarbonate can be used to assess C...Continue Reading

Citations

Nov 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·C L Kien, R E McClead
Oct 28, 2019·Isotopes in Environmental and Health Studies·Peter JunghansMichael Derno
Nov 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·C A HorswillK S McCoy
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Jul 1, 2006·Journal of Biosciences·T RajA V Kurpad
Dec 9, 2015·Isotopes in Environmental and Health Studies·Peter JunghansAnne-Helene Tauson
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Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·P TirakitsoontornD M Cooper
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Jun 1, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Catherine Hambly, Christian C Voigt

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