Oral administration effects of β-d-mannuronic acid (M2000) on Th17 and regulatory T cells in patients with ankylosing spondylitis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Mohammad Javad FattahiAbbas Mirshafiey

Abstract

To explore the effects of β-d-mannuronic acid (M2000) on levels of Th17, regulatory T (Treg) cells and their related cytokines in patients with ankylosing spondylitis (AS). 30 AS patients and 15 age and sex-matched healthy individuals were enrolled in this study. The frequencies of Th17 and Treg cells and serum levels of related cytokines were measured by flow cytometry analysis and ELISA respectively, before (baseline) and 3 months after M2000 therapy. Significantly higher baseline Th17 cells and serum IL-17, TNF-α and IL-6 were observed in AS patients than in normal controls, whereas baseline levels of Treg cells and serum IL-10 were not significantly different between AS patients and healthy controls. After M2000 therapy, frequencies of Th17 and serum levels of IL-17 and IL-6 significantly decreased in AS patients. The frequencies of Treg cells and serum level of IL-10 were not significantly changed, in comparison to before therapy. Moreover, the correlation analysis showed that frequencies of Th17 and levels of IL-17, TNF-α and IL-6 were positively correlated with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) scores, whereas Treg cells were revealed to b...Continue Reading

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Citations

Feb 18, 2020·Journal of Clinical Pharmacology·Afshin GhaderiAbbas Mirshafiey
Apr 7, 2019·Seminars in Immunopathology·Lisa GöschlMichael Bonelli
Nov 28, 2019·Journal of Immunology Research·Na-Lin LaiXiao-Feng Li
Dec 28, 2019·Current Drug Discovery Technologies·Nada A G GaafarAbbas Mirshafiey

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