PMID: 20127036Feb 4, 2010Paper

Oral administration of a galactooligosaccharide preparation inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice

International Journal of Molecular Medicine
Soichi Tanabe, Satomi Hochi

Abstract

Anti-allergic effects of galactooligosaccharide (GOS), which is found in breast milk and frequently added to food for promoting health, were evaluated in a human-like mouse model of atopic dermatitis (AD). NC/Nga mice were fed 5.5% GOS for 8 weeks, and we examined whether this treatment suppressed the development of AD-like skin lesions in these mice. Mice fed GOS exhibited significantly less symptoms of dermatitis, reduced scratching frequency, and lower levels of serum total immunoglobulin E compared to control. At the end of the 8-week-experimental period, spleens were removed, and the splenocytes were stimulated with phorbol 12-myristate 13-acetate and ionomycin, following which production of cytokines and a chemokine was analyzed. Elevated levels of Th1 cytokines such as interferon-gamma were observed in splenocytes from GOS-fed mice. However, the levels of Th2 cytokines such as interleukin (IL)-13 were unchanged. Furthermore, GOS inhibited the production of inflammatory cytokines such as IL-1beta, IL-6, IL-17, and tumor necrosis factor-alpha but enhanced production of immunomodulatory IL-10. The results indicate that GOS effectively blocked AD-like skin lesions in the mice by at least partly inducing production of IL-10 a...Continue Reading

Citations

Oct 21, 2011·Journal of Biomedicine & Biotechnology·Tasuku OgitaSoichi Tanabe
Nov 26, 2014·Molecular Nutrition & Food Research·Shikha BhatiaH Rex Gaskins
Dec 24, 2014·Gut Microbes·Yvan VandenplasGigi Veereman
May 30, 2009·Advances in Immunology·Michiko K OyoshiRaif S Geha
Feb 14, 2017·Animal : an International Journal of Animal Bioscience·M A BouwhuisJ V O'Doherty
May 21, 2015·The British Journal of Nutrition·Yvan VandenplasYulia Dmitrieva
Apr 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min Geun SuhHyung Joo Suh
Jan 9, 2021·Frontiers in Pediatrics·Simona SestitoLicia Pensabene

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