Oral administration of allergen extracts from Dermatophagoides farinae desensitizes specific allergen-induced inflammation and airway hyperresponsiveness in rats

International Immunopharmacology
Qiang-Min XieXin-Wei Dong

Abstract

Clinically sublingual immunotherapy (SLIT) by using allergen extracts effectively alleviates the symptoms of allergic rhinitis and asthma. Supposed that oral administration of high-dose of allergen extracts imitates SLIT and may prevent IgE-related responses in allergic diseases, we investigated the effects of oral administration of allergen extracts from Dermatophagoides farinae (Derf) on allergen-induced inflammation and airway hyperresponsiveness (AHR) in a model of asthmatic rat. After administration to the specific Derf-sensitized rats with Derfdrop solution containing Derf1 and Derf2 extracts derived from Derf, the effects of Derfdrop on AHR, inflammatory cell accumulation, cytokine production in the bronchoalveolar lavage fluid and lung tissue, as well as serum IgE and IgG levels were investigated. Results indicated that Derfdrop not only dose-dependently prevented the AHR in response to methacholine, but also significantly reduced the serum total and allergen-specific IgE levels, all the maximal effects were achieved at dose of 5 mg/kg/d, and were as comparable as those of dexamethasone at dose of 1.0 mg/kg/d. Furthermore, oral administration of Derfdrop not only dose-dependently elevated allergen-specific serum IgG lev...Continue Reading

References

May 1, 1992·The Journal of Allergy and Clinical Immunology·T A Platts-MillsM D Champman
Apr 1, 1994·Immunology Letters·Y AramakiS Tsuchiya
Jan 1, 1997·The Journal of Allergy and Clinical Immunology·A G van HalterenG Kraal
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·J BousquetH J Malling
Nov 20, 1998·Allergy·H J MallingE Valovirta
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·S BenjaponpitakD T Umetsu
Feb 26, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R M O'BrienW R Thomas
Feb 26, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M MajoriA Pesci
May 15, 2001·American Journal of Respiratory Cell and Molecular Biology·M RussoB B Vargaftig
Feb 7, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M N SatoA J S Duarte
Feb 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S SharmaS T Holgate
Mar 19, 2003·The Journal of Allergy and Clinical Immunology·Giorgio Walter Canonica, Giovanni Passalacqua
Apr 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G PittnerR Valenta
Apr 20, 2004·Current Opinion in Allergy and Clinical Immunology·Giovanni PassalacquaGiorgio Walter Canonica
Oct 27, 2004·Immunology·Jessica StridStephan Strobel
Feb 3, 2005·International Immunopharmacology·Wei DuanW S Fred Wong
Jun 24, 2006·Allergy·C A AkdisM Akdis
Feb 16, 2008·Nature Reviews. Immunology·Stephen T Holgate, Riccardo Polosa
May 14, 2008·Current Opinion in Otolaryngology & Head and Neck Surgery·Robert E Esch
Aug 22, 2008·The New England Journal of Medicine·Arturo J Bonnin, Dawn M Zacharias

❮ Previous
Next ❯

Citations

Jun 15, 2011·Cellular & Molecular Immunology·Yi-Ling YeBor-Luen Chiang
Jan 17, 2009·Vaccine·Xiuxiang ZhangQingyu Wang
Feb 14, 2012·International Immunopharmacology·Lan XuQiang-min Xie
Jun 24, 2014·Yonsei Medical Journal·Kyung Eun LeeKyu Earn Kim
Sep 6, 2020·Genes·Dawid SzczepankiewiczAleksandra Szczepankiewicz
Oct 28, 2009·Current Opinion in Allergy and Clinical Immunology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.