Oral Administration of Brain Protein Combined With Probiotics Induces Immune Tolerance Through the Tryptophan Pathway.

Frontiers in Molecular Neuroscience
Yongxin HouHua Yan

Abstract

Excessive inflammation leads to secondary immune damage after traumatic brain injury (TBI). The intestinal mucosa is a key component of immune tolerance due to gut-brain axis regulation, but the curative effect is not optimal. Intestinal dysfunction impairs the establishment of immune tolerance in patients with TBI. Therefore, we orally administered brain protein (BP) combined with probiotics to induce immune tolerance and explored the mechanism by which the homeostasis of the microbiota contributes to the enhancement of curative effects by BPs. Herein, we demonstrated that patients with TBI and surgical brain injury (SBI) models of rats had obvious dysbiosis. Notably, the intestinal barrier, proinflammatory cytokines, and activation of microglia demonstrated that excessive inflammatory damage was better controlled in the combined group (oral administration of BP combined with probiotics) than in the BP group (oral administration of BP). Fundamentally, tandem mass tag (TMT)-based quantitative proteomics analysis revealed that BP and probiotics preferentially affect Try-related pathways. A series of experiments further confirmed that Indoleamine 2,3 dioxygenase (IDO)/Kynurenine (Kyn)/Aryl hydrocarbon receptor (AhR) expression wa...Continue Reading

References

Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Q WangP O Hasselgren
Jul 13, 2005·Neuropathology and Applied Neurobiology·G J GuilleminK M Cullen
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·William R WikoffGary Siuzdak
Aug 25, 2009·Journal of Neurotrauma·Jesse R FannKatherine G Schomer
Oct 27, 2009·Nature Reviews. Immunology·Jerrold R Turner
Aug 17, 2010·Bioinformatics·Robert C Edgar
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Jun 26, 2012·Brain, Behavior, and Immunity·Alok Kumar, David J Loane
Jun 26, 2012·Nature Reviews. Immunology·Richard L Gallo, Lora V Hooper
Sep 21, 2012·Journal of the International Society of Sports Nutrition·Manfred LamprechtJoachim F Greilberger
Feb 9, 2013·Science·Sebastian E WinterAndreas J Bäumler
Feb 26, 2013·Nature Reviews. Microbiology·Felix Sommer, Fredrik Bäckhed
Jun 4, 2014·World Journal of Gastrointestinal Pathophysiology·Andrea Moro CaricilliNiels Olsen Saraiva Câmara
Nov 20, 2014·BMC Gastroenterology·Stephan C BischoffJerry M Wells
Jan 27, 2015·Cell Host & Microbe·Jason L KubinakJune L Round
Jun 2, 2015·Frontiers in Immunology·Karin de Punder, Leo Pruimboom
Jun 5, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Troy D HubbardGary H Perdew
Aug 4, 2015·Scientific Reports·Troy D HubbardGary H Perdew
Aug 26, 2015·Nature Reviews. Neurology·Ying FuFu-Dong Shi
Oct 8, 2015·Trends in Neurosciences·Kristina G WitcherJonathan P Godbout
Nov 4, 2015·Frontiers in Cellular Neuroscience·John R KellyNiall P Hyland
Dec 25, 2015·The Lancet. Respiratory Medicine·Robert P Dickson
Jul 10, 2016·Neuropharmacology·P J KennedyG Clarke
Dec 3, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jose Henrique LedoSergio T Ferreira
Jul 26, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xia ChenFei Guo

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
exe
SPSS
LEfSe
SPSS Statistics
QIIME
ReAdW

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Clinical Reviews in Allergy & Immunology
S BlumE J Schiffrin
Pneumonologia i alergologia polska
I Sokolnicka
Journal of Dental Hygiene : JDH
Denise M Bowen
The British Journal of Surgery
G C O'Sullivan
The Veterinary Record
H Schumm
© 2021 Meta ULC. All rights reserved