Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats

The Journal of Toxicological Sciences
Yoshinori OkamotoNakao Kojima

Abstract

Propolis, a natural product derived from plants by honeybees, is a mixture of several hundred chemicals, including flavonoids, coumaric acids, and caffeic acids, some of which show estrogen-like activity. In this study, the estrogenic activity of crude ethanolic extract of Brazilian propolis was determined using several in vitro and in vivo assays. Propolis was found to bind to human estrogen receptors (ERs). Furthermore, propolis induced the expression of estrogen-responsive genes in ER-positive MCF-7 and Ishikawa cells. These in vitro assays suggest that propolis exerts estrogenic activity; therefore, in vivo experiments were conducted using ovariectomized rats. Oral administration of propolis (55 or 550 mg/kg/day for 3 days) significantly increased uterine wet weight and luminal epithelium thickness in comparison with the corresponding values in the corn oil-treated control group. Moreover, propolis induced ductal cell proliferation in the mammary glands. These effects were completely inhibited by full ER antagonist ICI 182,780, confirming that the effects of propolis are mediated by the ER. Our data show that oral intake of propolis induces estrogenic activity in ER-expressing organs in vivo and suggest that Brazilian propo...Continue Reading

References

Jun 19, 1997·The New England Journal of Medicine·F GrodsteinF E Speizer
Jul 3, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G A Burdock
Aug 9, 2002·Journal of Agricultural and Food Chemistry·William H TollesonDean W Roberts
Sep 21, 2002·Journal of Ethnopharmacology·Yun Seon SongEun-Hee Park
Sep 2, 2003·Environmental Health Perspectives·Jun KannoWilliam Owens
Mar 30, 2004·Archives of Biochemistry and Biophysics·Kazuo ShimizuKazuki Kanazawa
Jun 7, 2005·Molecular Nutrition & Food Research·Hester van der WoudeIvonne M C M Rietjens
Jan 31, 2006·Journal of Natural Products·Chihiro ItoHiroshi Furukawa
Jan 10, 2008·International Journal of Cancer. Journal International Du Cancer·Yoshinori OkamotoShinya Shibutani
May 2, 2008·Chemical Research in Toxicology·Yoshinori OkamotoShinya Shibutani
Jan 26, 2010·Toxicology Letters·Yoshinori OkamotoShinya Shibutani
Oct 21, 2010·JAMA : the Journal of the American Medical Association·Rowan T ChlebowskiUNKNOWN WHI Investigators
Feb 1, 2011·Journal of the National Cancer Institute·Valerie BeralUNKNOWN Million Women Study Collaborators
Dec 12, 2012·Life Sciences·Xiaoping LiuShinya Shibutani
Apr 2, 2013·Journal of the National Cancer Institute·Rowan T ChlebowskiRoss L Prentice

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Citations

Jan 23, 2017·BMC Complementary and Alternative Medicine·Stéphane ZingueDieudonné Njamen

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