Oral administration of cadmium depletes intratesticular and epididymal iron levels and inhibits lipid peroxidation in the testis and epididymis of adult rats

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Sunny O AbarikwuRobinson Ohanador

Abstract

Cadmium (Cd)-induced tissue injury depends on the accumulated Cd which differentially affects endogenous iron (Fe). To investigate this, adult rats were treated by oral gavage with Cd (50 mg/kg body wt.) once a week for 15, 30 and 60 days and sacrificed a day after last administration. After the 15th and 30th day of treatment, Cd had no effect on thiobarbituric acid reactive substances (TBARS) and endogenous Fe levels but exhibited anti-androgenic effects (p < 0.05) and caused histological damages. At day 60, Cd was accumulated by 156.30% and 364.77% above control values at concentrations that decreased endogenous Fe levels by 46.41% and 50.31% in the testis and epididymis respectively. The histological damages were characterized by decreased tubular diameter, damage to the epithelium leading to loss of tubular germ cells and absent of spermatozoa in the epididymal lumen. Although myeloperoxidase activities were increased, TBARS levels were found to decrease significantly at day 60 in the serum, testis and epididymis suggesting that the histological damages were not caused by lipid peroxidation. Furthermore, TBARS correlated negatively with Cd in the testis (r = -0.251, p < 0.05) and epididymis (r = -0.286, p < 0.05); Fe correl...Continue Reading

Citations

Jan 4, 2020·Biological Trace Element Research·Viviane Gorete Silveira MouroSérgio Luis Pinto da Matta
Oct 7, 2018·Biological Trace Element Research·Sunny O AbarikwuRobinson Ohanador
Jun 17, 2020·Drug and Chemical Toxicology·Sunny O AbarikwuEugene N Onyeike
Apr 29, 2019·Biological Trace Element Research·Viviane Gorete Silveira MouroSérgio Luis Pinto da Matta
Aug 8, 2020·Drug and Chemical Toxicology·Sunny O AbarikwuChigozie L Onuah
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Viviane G S MouroSérgio L P Matta
Jan 6, 2021·Biological Trace Element Research·Viviane Gorete Silveira MouroSérgio Luis Pinto da Matta
Nov 30, 2020·Reproductive Toxicology·Joel Hernández-RodríguezMarcela Arteaga-Silva
Mar 19, 2021·Drug and Chemical Toxicology·Sunny O AbarikwuAdaba F S Wokoma

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