Oral administration of desloratadine prior to sensitization prevents allergen-induced airway inflammation and hyper-reactivity in mice

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
K BlümchenE Hamelmann

Abstract

Histamine-1-receptor (H1R)-antagonists were shown to influence various immunological functions on different cell types and may thus be employed for immune-modulating strategies for the prevention of primary immune responses. The aim of this study was to investigate the effects of an H1R-antagonist on allergen-induced sensitization, airway inflammation (AI) and airway hyper-reactivity (AHR) in a murine model. BALB/c mice were systemically sensitized with ovalbumin (OVA) (six times, days 1-14) and challenged with aerosolized allergen (days 28-30). One day prior to the first and 2 h prior to every following sensitization, mice received either 1 or 0.01 microg of desloratadine (DL) or placebo per os. Sensitization with OVA significantly increased specific and total IgE and IgG1 serum levels, as well as in vitro IL-5 and IL-4 production by spleen and peribronchial lymph node (PBLN) cells. Sensitized and challenged mice showed a marked eosinophilic infiltration in broncho-alveolar lavage fluids and lung tissues, and developed in vivo AHR to inhaled methacholine. Oral treatment with DL prior to OVA sensitization significantly decreased production of OVA-specific IgG1, as well as in vitro Th2-cytokine production by spleen and PBLN cell...Continue Reading

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Citations

Jan 4, 2008·Nature Reviews. Drug Discovery·Robin L ThurmondPaul J Dunford
May 9, 2006·The Journal of Clinical Investigation·Paul J BryceHans C Oettgen
Mar 6, 2007·European Journal of Pharmacology·Keiko SuzukiYasuaki Shimizu
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Jun 13, 2017·Experimental Dermatology·Gema TarrasónNúria Godessart

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