Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Maria Giulia MutoloNicola Pescosolido

Abstract

To evaluate the effects of a food supplement containing forskolin, homotaurine, carnosine, folic acid, vitamins B1, B2, B6, and magnesium in patients with primary open angle glaucoma (POAG) already in treatment and compensated by intraocular pressure (IOP)-lowering drugs, during a period of 12 months. Twenty-two patients (44 eyes) with POAG, with their IOP compensated by topical drugs, were enrolled and randomly assigned to the food supplement or control treatment group. The additional food supplement treatment consisted of 2 tablets per day (1 in the morning, 1 in the evening) given for 1 year of a balanced association of homotaurine, Coleus forskohlii root extract, L-carnosine, folic acid, vitamins B1, B2, B6, and magnesium. Pattern Electroretinogram (PERG) amplitude, foveal sensitivity obtained with the visual field analyzer frequency doubling technology, and IOP were detected at enrollment (T0), 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4). We observed in treated patients a significant further decrease of IOP and an improvement of PERG amplitude at 6, 9, and 12 months, and foveal sensitivity at 12 months. All values remained substantially stable in control patients. The results of the present pilot study ...Continue Reading

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Citations

Oct 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Idan HechtZvia Burgansky-Eliash
Sep 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carlota Saldanha
Oct 4, 2020·European Journal of Ophthalmology·Sayena JabbehdariThasarat Sutabutr Vajaranant
Nov 23, 2017·Oxidative Medicine and Cellular Longevity·Sergio DavinelliGiovanni Scapagnini
Jan 1, 2017·Advances in Pharmacological Sciences·Dario RuscianoNicola Pescosolido
Oct 22, 2020·Nutrients·Annagrazia AdornettoRossella Russo
Oct 28, 2020·Antioxidants·Jose Javier Garcia-MedinaMonica Del-Rio-Vellosillo

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