Oral administration of heat-killed Lactobacillus plantarum strain b240 protected mice against Salmonella enterica Serovar Typhimurium

Bioscience, Biotechnology, and Biochemistry
Hiroki IshikawaT Matsumoto

Abstract

The purpose of this study was to investigate the effects of heat-killed Lactobacillus plantarum strain b240 (b240) on systemic infection by Salmonella enterica serovar Typhimurium (S. Typhimurium) and to determine the mechanism by which b240 protects against infection. Mice were administered either b240 or saline orally for 3 weeks, and then inoculated with S. Typhimurium. The mice treated with b240 were significantly protected against S. Typhimurium as compared to those fed saline. Moreover, translocation of S. Typhimurium into each organ tested in the mice that received b240 tended to be less than in the control mice. An important mechanism of protection against infection was demonstrated by the ability of b240 to inhibit both binding by and invasion of S. Typhimurium into cells. These results indicate that nonviable lactic acid bacteria also play important roles in preventing infection by enteric pathogens.

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Citations

Jan 2, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yasuyuki SugasawaKazuhiro Tateda
Jun 25, 2013·European Journal of Pharmacology·Jin YangXiao-dan Wang
Aug 30, 2019·Probiotics and Antimicrobial Proteins·Aleksandra OłdakDanuta Kołożyn-Krajewska
May 28, 2019·International Journal of Molecular Sciences·Núria PiquéDavid Miñana-Galbis
May 16, 2020·Critical Reviews in Food Science and Nutrition·Aziz Homayouni RadAmin Abbasi
Jan 9, 2021·Frontiers in Microbiology·Wenjun DengSteven C Ricke
Mar 16, 2021·Critical Reviews in Food Science and Nutrition·Amin AbbasiNayyer Shahbazi

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