Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis

Journal of Neuroimmunology
S A BrodM Pappolla

Abstract

Chronic relapsing experimental autoimmune encephalitis (CR-EAE) is an inflammatory process of the central nervous system (CNS) that closely resembles the human disease multiple sclerosis (MS). EAE was induced in SJL/J mice and following recovery from the initial attack, animals were fed varying doses of human or murine interferon alpha (IFN-alpha), or mock IFN three times per week. After relapse, concanavalin A-activated spleen cells were transferred adoptively from orally fed animals into recipient animals. Oral administration of human or murine IFN-alpha suppressed relapse in actively immunized animals, modified adoptive transfer of EAE, and decreased mitogen/antigen proliferation and IFN-gamma secretion in both donors and recipients. IFN-alpha acts orally by modifying the encephalitogenicity of donor spleen T cells.

References

Dec 1, 1992·Journal of Interferon Research·P L WittE C Borden
Nov 11, 1992·Proceedings of the Society for Experimental Biology and Medicine·W R FleischmannC M Fleischmann
Feb 1, 1990·Annals of Neurology·A NoronhaM A Jensen
Sep 1, 1990·Journal of Neuropathology and Experimental Neurology·R A SobelM B Lees
Oct 1, 1987·Journal of Interferon Research·R A DiezE Falcoff
Dec 1, 1985·Journal of Neuroimmunology·C FeurerS Cammisuli
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M StreuliC Weissmann
Jan 1, 1982·Immunological Communications·S L Abreu
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T M Aune, C W Pierce
Jan 1, 1983·International Archives of Allergy and Applied Immunology·S L AbreuR Sowinski
Mar 1, 1980·The Journal of Experimental Medicine·A S KadishB R Bloom
Feb 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A BrodJ T Phillips
Apr 5, 2012·Journal of Reproductive Immunology·Adam J KarpalaAndrew G D Bean

❮ Previous
Next ❯

Citations

Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A Brod
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A Brod
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·V Bocci
Jan 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T J Kaido
Oct 22, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y NagaoA Uemura
Mar 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A BrodGregory L Shipley
Mar 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A Brod, Zachary Hood
Apr 29, 2010·The Journal of Veterinary Medical Science·Akira ItoToru Gotanda
Jan 27, 2016·Journal of the Neurological Sciences·Staley A Brod
Nov 15, 2012·Cytokine·Staley A Brod, Victoria Bauer
Jun 19, 2012·Journal of Neuroimmunology·Staley A Brod, Victoria L Bauer
Nov 18, 2010·Journal of Neuroimmunology·Staley A Brod, Zachary M Hood
Jul 4, 2016·Cytokine·Staley A Brod
Jul 27, 2011·Journal of Autoimmunity·Melissa A Landek-SalgadoPatrizio Caturegli
Feb 26, 2013·Journal of Reproductive Immunology·Konstantinos PatasStefan M Gold
Jan 2, 2007·Journal of Neuroimmunology·Staley A Brod, Zachary Hood
Feb 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·S A BrodJ S Wolinsky
Jun 14, 2000·Transplantation·S A BrodS Stepkowski
Sep 28, 1999·Current Opinion in Neurology·J H NoseworthyH P Hartung
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark D MannieJ Lori Blanchfield
Jan 20, 2011·Autoimmunity·Staley A Brod, Zachary M Hood
Sep 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Duncheng WangMark D Mannie
Dec 10, 2019·Journal of the Neurological Sciences·Landon J DittelStaley A Brod
Jul 27, 1999·Cytokine·S A BrodJ S Wolinsky
Nov 27, 2007·Journal of Neuroimmunology·Staley A Brod, Zachary M Hood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.