Oral administration of Lactobacillus fermentum post-weaning improves the lipid profile and autonomic dysfunction in rat offspring exposed to maternal dyslipidemia.

Food & Function
Yohanna de OliveiraJosé Luiz de Brito Alves

Abstract

Maternal dyslipidemia alters the gut microbiota composition and contributes to the development of arterial hypertension (AH) in offspring. Here, we evaluated the effects of a new Lactobacillus fermentum probiotic formulation given post-weaning on cardiometabolic parameters and gut microbiota in male and female rat offspring from dams exposed to maternal dyslipidemia during pregnancy and lactation. Wistar rats (n = 14) were fed with a control diet (CTL = 7) or a dyslipidemic diet (DLP = 7) during pregnancy and lactation. After weaning, male and female offspring received a standard diet up to 90 days of life. Rats were allocated into three groups: CTL group + saline solution (n = 14); DLP group + saline solution (n = 14) and DLP group receiving a probiotic cocktail (n = 14). A vehicle or probiotic formulation containing L. fermentum 139, L. fermentum 263 and L. fermentum 296 (ratio 1 : 1 : 1, 1 × 109 CFU mL-1) was administered daily by oral gavage for 8 weeks. The intervention with the probiotic formulation of L. fermentum in male and female offspring reduced total cholesterol (TC) and increased HDL-c, but did not affect the insulin resistance induced by maternal dyslipidemia. Additionally, the male and female rats that received ...Continue Reading

References

Feb 16, 2002·International Journal of Food Microbiology·Tiiu KullisaarAnn Kilk
Nov 10, 2010·Prikladnaia biokhimiia i mikrobiologiia·T KullisaarM Zilmer
Oct 15, 2013·Applied Microbiology and Biotechnology·Catherine Tomaro-DuchesneauSatya Prakash
Apr 15, 2015·Hypertension·Tao YangMansour Mohamadzadeh
Aug 11, 2015·Molecular Nutrition & Food Research·Manuel Gómez-GuzmánJuan Duarte
Nov 5, 2016·Respiratory Physiology & Neurobiology·Barbara J MorganJohn M Dopp
Nov 2, 2016·Circulation Research·Monica M SantistebanMohan K Raizada
Mar 21, 2017·Current Hypertension Reports·Iñaki Robles-VeraJuan Duarte
Jul 1, 2017·Food & Nutrition Research·Smith Etareri EvivieXin Bian
Aug 25, 2017·Probiotics and Antimicrobial Proteins·Thatyane Mariano Rodrigues de AlbuquerqueEvandro Leite de Souza
Aug 25, 2017·Nature Reviews. Cardiology·Francine Z MarquesDavid M Kaye
Nov 28, 2017·The British Journal of Nutrition·Keyth Sulamitta L GuimarãesJosé Luiz de Brito Alves
Feb 8, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marinaldo Pacífico Cavalcanti NetoJosé Luiz de Brito Alves
Mar 1, 2018·World Journal of Gastrointestinal Pathophysiology·Caroline LinningeBodil Ohlsson
Jun 12, 2018·Molecular Metabolism·Tzu-Wen L CrossFederico E Rey
Jun 14, 2018·The EPMA Journal·Rostyslav V BubnovMykola Ya Spivak
Jan 17, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Emmanuel Veríssimo de AraújoJosé Luiz de Brito Alves
Apr 27, 2019·Biology of Sex Differences·Anna L BealeFrancine Z Marques
Jun 12, 2019·Biology of Sex Differences·Alexander C RazaviLydia A Bazzano
Aug 23, 2019·Probiotics and Antimicrobial Proteins·Sasikumar Arunachalam PalaniyandiSeung Hwan Yang
Oct 24, 2019·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Raíssa G S CavalcanteJosé L de Brito Alves

❮ Previous
Next ❯

Citations

Feb 13, 2021·Obstetrics and Gynecology Clinics of North America·Pardis Hosseinzadeh, Robert Wild

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA

Software Mentioned

CardioSeries
Prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.