PMID: 9557957Apr 29, 1998Paper

Oral administration of one dose of cholera toxin induces a systemic immune response prior to a mucosal immune response by a direct presentation in the spleen

Immunology Letters
R BenedettiJ Fló

Abstract

In the present report the results indicate that the oral administration of one dose of CT in rats results in an antibody immune response in the spleen 48 h later, whereas no antitoxin antibody forming cells were found in the Peyer patches (PP), mesenteric lymph node (MLN) and lamina propria (LP) of the small intestine. At this time the main isotype of the antitoxin antibodies in the spleen were IgG and IgM, 5 days after the priming, few antitoxin AFC were observed in the MLN, IgG being the main isotype, whereas no IgM antitoxin AFC were found. At 1 week after priming the number of antitoxin AFC in the MLN reached similar values to those observed in the spleen. When cells from the spleen of rats primed orally with one dose of CT were cultured during 4 days in the presence of inhibitory doses of anti-Ia MAb (OX6), the number of antitoxin AFC was diminished when compared with that observed when cells were cultured in the absence of anti-Ia. The main isotype of antitoxin AFC observed when cells were analyzed after culture was IgM and it was the isotype most affected by the treatment with MAb anti-Ia. These results strongly suggest that an in situ presentation of the antigen did occur in the spleen. On the other hand, when the secon...Continue Reading

Citations

Jan 20, 2010·Archives of Medical Research·Sergio Sifontes-RodríguezNiurka Rodríguez-Pérez
Aug 23, 2006·Microbiology and Immunology·Mariano E Fernandez-MiyakawaNancy A Mateo
Oct 23, 2001·Research in Veterinary Science·M C RebelattoH Hogenesch
Oct 28, 2015·ACG Case Reports Journal·Grigory RoginskyEli D Ehrenpreis
Sep 9, 2011·Molecular Biotechnology·Shirin Tarahomjoo

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