Oral administration of paeoniflorin attenuates allergic contact dermatitis by inhibiting dendritic cell migration and Th1 and Th17 differentiation in a mouse model

International Immunopharmacology
Dongmei ShiWeida Liu

Abstract

Allergic contact dermatitis (ACD) is a hapten-specific CD4(+) T-cells mediated inflammatory response of the skin. Its pathomechanism involves 2 phases, an induction phase and an elicitation phase. Langerhans cells (LCs) and dendritic cells (DCs) in the skin play key roles in presenting low molecular weight chemicals (haptens) to the lymph nodes. Therefore, inhibition of the migration of LCs or DCs and T-cell proliferation is each expected to control ACD disease. To explore the effectiveness of paeoniflorin (PF) on the migration of LCs and T-cell proliferation in vivo, we establish a murine model of ACD, promoted by repeated exposure to an allergen (specifically 1-Chloro-2,4-dinitrobenzene (DNCB)). Administration of PF inhibits DC migration in this DNCB-induced model in the induction phase. As a result, epidermal LC density in the elicitation phase increased in PF-treated mice when compared to PF-untreated mice. At the same time, PF reduced IFN-γ(+)CD4(+) and IL-17(+)CD4(+) T cells proliferation (but not IL-4(+)CD4(+) T cells proliferation), leading to an attenuated cutaneous inflammatory response. Consistent with this T-cell proliferation profile, secretions of IFN-γ and IL-17 were reduced and IL-10 secretion increased in PF-tr...Continue Reading

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Citations

Jan 2, 2016·Immunologic Research·Dan ChenGuang Li
Mar 26, 2016·Expert Review of Clinical Immunology·Shannon K QuirkDevendra K Agrawal
Nov 6, 2012·Progress in Lipid Research·Alexandra C Kendall, Anna Nicolaou
Mar 3, 2017·Chinese Journal of Integrative Medicine·Youngchul JungHyungwoo Kim
Mar 7, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Zuoqi XiaoBo Ouyang
Apr 22, 2020·Immunopharmacology and Immunotoxicology·Weihua LiZhigang Wang
Jul 19, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan-Xi ZhouCheng Peng

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