PMID: 2101487Sep 1, 1990Paper

Oral administration of TNP-Lactobacillus conjugates in mice: a model for evaluation of mucosal and systemic immune responses and memory formation elicited by transformed lactobacilli

Research in Microbiology
K GerritseE Claassen

Abstract

Safe live vector systems are being developed for oral delivery of antigens. A transformation system for indigenous Lactobacillus species of the gastrointestinal tract is described. Model systems were set up to evaluate immune responses. Orally administered trinitrophenylized (TNP) Lactobacillus were examined for their ability to induce immunological memory formation via determination of specific antibody titres in serum. We demonstrate a direct correlation between the level of systemic memory formation, as revealed by specific anti-TNP IgG serum antibodies, and the TNP substitution ratio of the Lactobacillus suspension used for oral priming. The specific IgG anti-TNP serum titres were comparable to or even higher than the titres of parental intraperitoneally primed animals. These results demonstrate the feasibility of using orally administered antigen-Lactobacillus as a future approach to vaccination.

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Citations

Sep 1, 1993·FEMS Microbiology Reviews·P Marteau, J C Rambaud
Mar 16, 2000·Developmental and Comparative Immunology·W I MuirA J Husband
Aug 15, 1998·International Journal of Food Microbiology·P H PouwelsP L Conway
Mar 23, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Joseph U IgietsemeHarlan D Caldwell
May 26, 1999·Clinical and Experimental Immunology·C HessleA E Wold
Oct 1, 1996·Antonie van Leeuwenhoek·J M WellsR W Le Page
Mar 1, 1995·Journal of Dairy Science·E J SchiffrinA Donnet-Hughes
Jan 1, 1993·Antonie van Leeuwenhoek·P H Pouwels, R J Leer
May 8, 2014·European Journal of Immunology·Jessica QuintinMihai G Netea
Oct 19, 2019·Vaccines·Allison C Vilander, Gregg A Dean
Mar 25, 2000·The American Journal of Clinical Nutrition·S N Meydani, W K Ha

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