PMID: 9652811Jul 4, 1998Paper

Oral administration of tritiated water (HTO) in mouse. III: Low dose-rate irradiation and threshold dose-rate for radiation risk

International Journal of Radiation Biology
O YamamotoN Fujimoto

Abstract

To investigate the biological effect of tritium on mouse at low dose-rates. Mice ([C57BL/6N x C3H/He]F1) were exposed to beta-rays by continuous administration of tritiated drinking water throughout their lives at low dose-rates of 3.6, 0.9, and 0.2 mG/day. Including the previous study, the tumour frequency was 70 to approximately 80% for exposure in the range 240 mGy/day to 9.6 mGy/day. Frequency of tumours decreased with decrease of dose-rate to 50% comparable to the controls. Restricting to thymic lymphomas, a linear relationship in a semi-log plot was found between the frequency and the dose-rate above a threshold dose-rate of 12 mGy/day. There was a 'tail' to this relationship down to 0.9 mGy/day. A similar pattern resulted for the relationship between the life-shortening and the dose-rate. The threshold dose-rate of 3H beta-rays, 2 mGy/day (with a tail down to 0.2 mGy/day), was much lower than that of gamma-rays, 20 mGy/day (tail down to 2 mGy/day) derived from other studies. These studies suggest that there exists the threshold dose-rate in the biological effects of radiation, and that the threshold dose-rate for 60Co gamma-irradiation is higher than that for 3H beta-irradiation.

Citations

Sep 7, 2001·Uchū Seibutsu Kagaku·T Ohnishi, S Nagaoka
Jan 22, 2011·International Journal of Radiation Biology·Hiroshi Tanooka
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Bobby R Scott
Mar 24, 2007·Experimental Hematology·Ludwig E FeinendegenRonald D Neumann
Dec 19, 2007·Radiation and Environmental Biophysics·Ludwig FeinendegenEberhard O Voit
Jun 30, 2010·Dose-response : a Publication of International Hormesis Society·Alexander M Vaiserman
Jan 11, 2013·Dose-response : a Publication of International Hormesis Society·Charles L Sanders
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·B R Scott
Oct 21, 2017·Journal of Radiation Research·Haruki NagashimaHiroshi Tauchi
Jul 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·Ludwig E FeinendegenCharles A Sondhaus
Jul 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·Bobby R ScottVernon E Walker
Jan 1, 2003·Nonlinearity in Biology, Toxicology, Medicine·Bobby R ScottVernon Walker
Apr 4, 2003·Journal of Radiation Research·Hong YinAkihiro Ito
Feb 11, 2005·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·A RealI Zinger
Jul 28, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yi QuanJinxian Lin

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