Oral and intraperitoneal acute toxicity studies of yessotoxin and homoyessotoxins in mice

Toxicon : Official Journal of the International Society on Toxinology
A TubaroT Yasumoto

Abstract

The acute toxicity of yessotoxin (YTX), homoyessotoxin (homoYTX) and 45-hydroxy-homoyessotoxin (45-OH-homoYTX) has been studied in comparison to that of okadaic acid (OA), the main diarrhogenic toxin, both after intraperitoneal (i.p.) and oral administration. After i.p. administration, homoYTX and YTX showed similar lethality (LD(50)=444 microg/kg and 512 microg/kg), higher than that of OA (LD(50)=225 microg/kg), while 750 microg/kg of 45-OH-homoYTX did not cause death. OA induced the already known toxic signs: before death, mice were motionless and cyanotic; small intestine and liver damage were shown at post-mortem. Mice treated with YTX and homoYTX were restless and jumped before death; necroscopy did not show major changes. After oral treatment, 2 mg/kg of OA induced diarrhoea and body weight loss, causing 4/5 deaths; necroscopy and/or histology revealed degenerative lesions to small intestine, forestomach and liver (confirmed by increased plasma transaminase), but no myocardium alterations. On the contrary, the oral treatment with YTX (1 and 2 mg/kg) and its derivatives (1 mg/kg) did not cause any death or signs of toxicity, except some ultrastructural myocardiocyte alterations, adjacent to capillaries, such as cytoplasmic...Continue Reading

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Citations

Mar 17, 2005·Marine Environmental Research·Simon M MitrovicKevin J James
Mar 23, 2004·Toxicon : Official Journal of the International Society on Toxinology·A FranchiniE Ottaviani
Mar 31, 2004·Toxicon : Official Journal of the International Society on Toxinology·A TubaroT Yasumoto
May 26, 2005·Toxicon : Official Journal of the International Society on Toxinology·Ingunn A SamdalChristopher O Miles
Jun 5, 2012·Chemical Research in Toxicology·Luis M Botana
Feb 25, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·A TubaroP Lorenzon
Mar 20, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Carlos GarciaNéstor Lagos
Jun 15, 2011·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Toshiyuki Suzuki, Michael A Quilliam
Aug 30, 2008·Marine Drugs·Beatriz PazJosé J Fernández
Aug 30, 2008·Marine Drugs·Da-Zhi Wang
Apr 23, 2010·Marine Drugs·Antonella FranchiniEnzo Ottaviani
Nov 15, 2013·Toxins·Rex Munday, John Reeve
Mar 19, 2014·Environmental Toxicology and Pharmacology·Nai-sheng ZhangWei-dong Yang
Feb 8, 2014·Archives of Toxicology·Katrin KittlerDominique Hurtaud-Pessel
Sep 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Valeria Dell'OvoAurelia Tubaro
Dec 12, 2012·The Journal of Organic Chemistry·Takeo SakaiYuji Mori
Feb 2, 2016·Marine Drugs·Amparo AlfonsoLuis M Botana
Mar 24, 2011·Toxicon : Official Journal of the International Society on Toxinology·John A B AasenTore Aune
Mar 10, 2010·Toxicon : Official Journal of the International Society on Toxinology·Humberto J DomínguezJosé J Fernández
Dec 23, 2009·Toxicon : Official Journal of the International Society on Toxinology·Anke EhlersAlfonso Lampen
Nov 21, 2009·Toxicon : Official Journal of the International Society on Toxinology·Humberto J DominguezJosé J Fernández
Aug 4, 2009·Toxicon : Official Journal of the International Society on Toxinology·Carlotta Francesca OrsiSamuele Peppoloni
Aug 8, 2009·Toxicon : Official Journal of the International Society on Toxinology·A TubaroC Florio
Jul 29, 2008·Toxicon : Official Journal of the International Society on Toxinology·Tore AuneStig Larsen
Jun 25, 2008·Toxicon : Official Journal of the International Society on Toxinology·Zouher AmzilVéronique Savar
Apr 12, 2008·Toxicon : Official Journal of the International Society on Toxinology·A TubaroS Sosa
Dec 25, 2007·Toxicology·Federica Callegari, Gian Paolo Rossini
Mar 31, 2007·Toxicon : Official Journal of the International Society on Toxinology·Beatriz PazJosé M Franco
Feb 8, 2006·Environmental Toxicology·Ludovic Le HégaratValérie Fessard
Dec 8, 2004·Toxicon : Official Journal of the International Society on Toxinology·Christopher O MilesVeronica Beuzenberg
Aug 24, 2004·Toxicon : Official Journal of the International Society on Toxinology·Christopher O MilesA Lincoln MacKenzie
Jul 1, 2004·Toxicon : Official Journal of the International Society on Toxinology·A FranchiniE Ottaviani
Oct 24, 2006·Toxicon : Official Journal of the International Society on Toxinology·Silvia PierottiGian Paolo Rossini
Sep 5, 2006·Toxicology·Federica CallegariGian Paolo Rossini

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