Oral and maxillofacial manifestations of chronic kidney disease-mineral and bone disorder: a multicenter retrospective study

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Flávia Sirotheau Corrêa PontesHélder Antônio Rebelo Pontes

Abstract

To describe the oral and maxillofacial manifestations of patients diagnosed with chronic kidney disease-mineral and bone disorders. Over a 13-year period, clinicopathologic data of patients diagnosed with CKD-MBD who had oral and maxillofacial alterations were retrieved from the files of 4 Brazilian institutions. Data included clinical, radiographic, microscopic, and biochemical findings; treatment employed; and follow-up status. Twenty-one cases were identified, with 13 patients diagnosed as brown tumor of hyperparathyroidism (BTH) and 8 as osteitis fibrosa/renal osteodystrophy (OF/RO) (4 of them clinically consistent with Sagliker syndrome). The mean age was 32.7 years, and the mandible was the most affected site (42.8%). OF/RO had an ill-defined "ground glass" radiographic appearance, and BTH produced well-defined radiolucent images. Biochemically the following mean values were obtained: parathormone 1511.07 pg/mL, calcium 9.25 mg/dL, phosphorus 5.19 mg/dL, alkaline phosphatase 941.55 U/L, urea 125.42 mg/dL, and creatinine 7.14 mg/dL. Treatment comprised vitamin D and calcium intake, parathyroidectomy, hemodialysis, renal transplantation, and local surgery. During follow-up, 5 patients with BTH were free of lesions, whereas ...Continue Reading

Citations

Oct 31, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Thaís Dos Santos Fontes PereiraRicardo Santiago Gomez
Dec 14, 2019·Oral and Maxillofacial Surgery·Luiz Carlos Moreira JuniorAdriano Rocha Germano
Nov 25, 2019·Journal of Bone and Mineral Metabolism·Carmen GrafChristoph Schmid
Jun 1, 2018·Case Reports in Dentistry·Nour MellouliNabiha Douki
Mar 21, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Carlo LajoloMichele Giuliani

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