Oral and oropharyngeal cancer in the West of Scotland-long-term outcome data of a prospective audit 1999-2001

The British Journal of Oral & Maxillofacial Surgery
Jeremy McMahonA G Robertson

Abstract

We prospectively studied patients from the west of Scotland who presented with a primary cancer of the oral cavity or oropharynx over a period of 24 months from November 1999, and report long-term outcomes and prognostic factors. A total of 481 patients had squamous cell carcinoma (SCC), 5-year disease-specific survival (DSS) was 50%, and overall survival (OS) was 35%. One hundred were not suitable for treatment with curative intent, and factors other than stage were important in this decision. Of those treated with curative intent, 249 had SCC of the oral cavity (5-year DSS 67%; OS 42%), and 132 had SCC of the oropharynx (5-year DSS 62%; OS 42%). Multivariate analysis showed that pathological nodal stage (p=0.051, 95% CI 0.998-1.955), and perineural invasion (p=0.001, 95% CI 0.186-0.666) were prognostic indicators. Improved results using intensive treatment protocols that have been seen in trials are not likely to translate directly into a general population of patients with head and neck cancer. Algorithms that allow several pathological prognostic indicators to be incorporated into decisions about adjuvant treatment should be used.

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Citations

Oct 4, 2015·The British Journal of Oral & Maxillofacial Surgery·Ben GreenPeter A Brennan
Oct 29, 2015·Journal of Cancer Research and Clinical Oncology·Nosayaba Osazuwa-PetersMark A Varvares
Oct 2, 2012·The British Journal of Oral & Maxillofacial Surgery·Gururaj ArakeriPeter A Brennan
May 29, 2012·The British Journal of Oral & Maxillofacial Surgery·D HammondP A Brennan
Mar 27, 2012·The British Journal of Oral & Maxillofacial Surgery·Caroline DruganSteven Thomas
Aug 3, 2010·The British Journal of Oral & Maxillofacial Surgery·Jeremy D McMahonRavi Jampana
May 6, 2015·The British Journal of Oral & Maxillofacial Surgery·A KanatasS N Rogers
Feb 24, 2015·International Journal of Oral and Maxillofacial Surgery·Y MatsushitaM Umeda
Dec 17, 2017·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·C M DouglasK MacKenzie
Apr 2, 2019·The Journal of Laryngology and Otology·F D BegbieJ Montgomery
Dec 21, 2016·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Katy GordonHeather Wallace
Feb 7, 2019·Frontiers in Oncology·Kate IngarfieldDavid I Conway
Nov 5, 2020·The British Journal of Oral & Maxillofacial Surgery·J McMahonJ McCaul
Jun 24, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Poolakkad S SatheeshkumarE Adjei Boakye

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