Oral and pre-absorptive sensing of amino acids relates to hypothalamic control of food intake in rainbow trout.

The Journal of Experimental Biology
Sara ComesañaSofia Morais

Abstract

To assess the putative role of taste and pre-absorptive sensing of amino acids in food intake control in fish, we carried out an oral administration with l-leucine, l-valine, l-proline or l-glutamic acid in rainbow trout (Oncorhynchus mykiss). Treatment with proline significantly reduced voluntary food intake at 2 h and 3 h after oral administration, while glutamic acid showed a less pronounced satiating effect at 3 h. The mRNA expression of taste receptor subunits tas1r1, tas1r2a, tas1r2b and tas1r3 was measured in the epithelium overlying the bony basihyal of the fish (analogous to the tetrapod tongue) at 10, 20 or 30 min following treatment. No significant changes were observed, except for a tas1r down-regulation by valine at 30 min. Of the downstream taste signalling genes that were analysed in parallel, plcb2 and possibly trpm5 (non-significant trend) were down-regulated 20 min after proline and glutamic acid treatment. The signal originated in the oropharyngeal and/or gastric cavity presumably relays to the brain as changes in genes involved in the regulation of food intake occurred in hypothalamus 10-30 min after oral treatment with amino acids. In particular, proline induced changes consistent with an increased anorexig...Continue Reading

References

Mar 24, 2000·Neuroscience Letters·M Asano-MiyoshiY Emori
Nov 7, 2001·The Journal of Biological Chemistry·Robert F Margolskee
Nov 9, 2005·Mechanisms of Development·Yoshiro IshimaruKeiko Abe
Nov 17, 2006·Nature·Jayaram ChandrashekarCharles S Zuker
May 25, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hideaki OikeKeiko Abe
Oct 11, 2007·The Journal of Biological Chemistry·Chihiro HisatsuneKatsuhiko Mikoshiba
May 17, 2008·Regulatory Peptides·Hans-Rudolf Berthoud
Jun 6, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sergio PolakofJosé L Soengas
Aug 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sergio PolakofJosé L Soengas
Apr 23, 2009·Physiology & Behavior·Margriet A B VeldhorstMargriet S Westerterp-Plantenga
Aug 19, 2009·Annals of the New York Academy of Sciences·Takashi KondohKunio Torii
May 21, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joan Sánchez-GurmachesIsabel Navarro
Apr 1, 2011·The Journal of Comparative Neurology·Makoto OhmotoIchiro Matsumoto
Jul 6, 2011·General and Comparative Endocrinology·Michael A Caruso, Mark A Sheridan
Dec 21, 2011·The Journal of Physiology·Keiko YasumatsuYuzo Ninomiya
Jul 16, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sergio Polakof, José L Soengas
Jul 31, 2013·The Journal of Physiology·Josua JordiFrançois Verrey
Jan 17, 2015·Nature·Alejo EfeyanDavid M Sabatini
Mar 18, 2015·Bioscience, Biotechnology, and Biochemistry·Shinji Okada
Oct 7, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Cristina Otero-RodiñoJosé L Soengas
Dec 25, 2015·Tissue Engineering. Part C, Methods·Nandakumar VenkatesanHong-Xiang Liu
Jul 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cristina VelascoJosé L Soengas
Jan 24, 2017·Frontiers in Neuroscience·Marta Conde-Sieira, José L Soengas
May 2, 2017·Frontiers in Endocrinology·Ivar RønnestadHélène Volkoff
Sep 28, 2017·Journal of Molecular Endocrinology·Cristina VelascoJosé L Soengas
Oct 20, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sara ComesañaJosé L Soengas
Feb 23, 2018·Journal of Molecular Endocrinology·José Luis SoengasMaría Jesús Delgado
Jul 31, 2018·International Journal of Food Sciences and Nutrition·Pengfei HanMinghai Fu
Sep 19, 2018·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Marta Conde-SieiraJosé L Soengas
Feb 23, 2019·Journal of Fish Biology·Alexander O Kasumyan
Nov 13, 2019·PloS One·Shingo TakaiNoriatsu Shigemura

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Citations

Mar 16, 2021·Frontiers in Neuroscience·José L Soengas

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