Oral antibody to interleukin-10 reduces growth rate depression due to Eimeria spp. infection in broiler chickens

Poultry Science
Jordan M SandMark Cook

Abstract

Eimeria spp. must be controlled in floor-reared poultry to prevent the onset of coccidiosis. Here we use an oral antibody to chicken IL-10 to prevent growth depression due to Eimeria spp. infection. Egg antibody directed against an antigenic peptide of IL-10 was produced in laying hens and measured using an ELISA. In the first experiment, egg yolk powder containing antibody to chicken IL-10 (vlpramqt conjugate) (anti-IL-10 yolk powder) was fed at 3.4 g/kg feed to determine growth response following mixed Eimeria spp. challenge. Chicks were fed either anti-IL-10 antibodies or control antibodies and challenged (d3) with either sterile saline or a 10× attenuated Eimeria spp. vaccine. Control-fed and Eimeria-challenged chicks grew 8.8% slower than those challenged with saline (P < 0.04), whereas anti-IL-10-fed Eimeria challenged chicks were not different from untreated controls. In the second trial a dose response was performed with doses of either 0 (control antibody), 0.34-, or 3.4-g anti-IL-10 yolk powder/kg feed. Control-fed, Eimeria-challenged chicks grew 10.6% slower than control saline-challenged chicks (P < 0.05); however, anti-IL-10-fed chicks fed either dose of anti-IL-10 were not different from saline-challenged chicks. ...Continue Reading

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Citations

May 5, 2016·Poultry Science·L R Berghman
Jun 28, 2016·Domestic Animal Endocrinology·M E CookJ M Sand
Nov 11, 2017·Poultry Science·Leon J Broom, Michael H Kogut
Nov 23, 2018·Genetics, Selection, Evolution : GSE·Kay BoultonDavid A Hume
May 21, 2018·Journal of Dairy Science·S M RaabisS M McGuirk
Dec 12, 2019·Frontiers in Immunology·Woo H KimHyun S Lillehoj
Jun 3, 2021·Parasite : Journal De La Société Française De Parasitologie·Thabile MadlalaMatthew Adekunle Adeleke

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