Abstract
In the randomized Balloon Angioplasty and Anticoagulation Study (BAAS), the addition of oral anticoagulants to aspirin significantly reduced early and late events after coronary angioplasty. However, bleeding episodes were increased. The present report studied the intensity and the duration of anticoagulation as predictors of thrombotic and bleeding events. A total of 530 patients, 34% of whom received a stent, were treated with aspirin plus coumarins. Half of the patients were randomized to angiographic follow-up. The target international normalized ratio (INR) was 2.1 to 4.8 during angioplasty and 6-month follow-up. Thrombotic events were death, myocardial infarction, target lesion revascularization, and thrombotic stroke. Bleeding complications were hemorrhagic stroke, major extracranial bleeding, and false aneurysm. "Optimal" anticoagulation was defined as an INR in the target range for at least 70% of the follow-up time. There were 17 early thrombotic events (3.2%), 7 early bleeding episodes (1.3%), and 10 false aneurysms (1.9%). The incidence rate for both early thrombotic and bleeding events was lowest in patients in the target range. A total of 61 late thrombotic events occurred (11.6%). Optimal anticoagulation was an i...Continue Reading
References
Nov 11, 1992·Journal of the American College of Cardiology·R S SchwartzE J Topol
Apr 1, 1992·Journal of the American College of Cardiology·A M LincoffE J Topol
Jul 1, 1992·American Heart Journal·P T VaitkusW K Laskey
Jul 31, 1987·The American Journal of Cardiology·L A Harker
Sep 1, 1987·Journal of the American College of Cardiology·K KohchiM Nobuyoshi
Dec 1, 1988·British Heart Journal·P UrbanA Rickards
Sep 21, 1995·The New England Journal of Medicine·P W SerruysK A Fox
Sep 21, 1995·The New England Journal of Medicine·J A BittlB Adelman
Jun 1, 1995·Journal of the American College of Cardiology·C J WhiteA Escobar
Apr 9, 1994·Lancet·E J TopolM Weston
Sep 1, 1994·Journal of the American College of Cardiology·P den HeijerK I Lie
May 1, 1996·Journal of the American College of Cardiology·A J AzarF R Rosendaal
Aug 1, 1997·Journal of the American College of Cardiology·M J WilliamsR A Stewart
Citations
Aug 2, 2003·Archives of Biochemistry and Biophysics·Stella Pelengaris, Mike Khan
Jun 24, 2003·Thrombosis Research·Jeffrey I Weitz
Apr 19, 2002·Biochimica Et Biophysica Acta·Werner LutzMartin Eilers
Feb 14, 2008·European Heart Journal·Yuichiro YanoYoichi Sakata
May 8, 2010·European Heart Journal·Gregory Y H LipUNKNOWN Consensus Document of European Society of Cardiology Working Group on Thrombosis
Nov 7, 2001·Cardiology in Review·F W Verheugt
Jan 10, 2012·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Melkon DomBourian, Lorne Holland
Jul 30, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Natalie OakeCarl van Walraven
Apr 21, 2005·Drugs & Aging·Bob A J van DeelenHuub A A M Maas
Oct 5, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·K E Juhani AiraksinenGregory Y H Lip
Oct 27, 2009·American Heart Journal·Willem Dewilde, Jurriën Ten Berg
Oct 1, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Antonios G ZiakasIoannis Styliadis
Apr 3, 2012·The American Journal of Cardiology·Tuomas KiviniemiKari Eino Juhani Airaksinen
Feb 8, 2006·The American Journal of Cardiology·Seifeddin S El-JackSuwatchai Pornratanarangsi
Jun 11, 2003·American Heart Journal·Steven Steinhubl, Peter Berger
Aug 25, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Konstantinos C Koskinas, Lorenz Räber
Jun 28, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Willem J M DewildeNicoline J Breet
Aug 20, 2016·International Journal of Cardiology·Mariusz KowalewskiGregory Y H Lip
Sep 24, 2010·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·W DewildeJ M Ten Berg