Oral Anticoagulants in Japanese Patients with Atrial Fibrillation and Active Cancer

Internal Medicine
Taku YasuiMasashi Fujita

Abstract

Objective Oral anticoagulants (OACs), which include direct oral anticoagulants (DOACs) and warfarin, are widely used for the prevention of thromboembolic events in patients with atrial fibrillation (AF). Cancer is associated with a prothrombotic state as well as an increased bleeding risk. Few data are available on the efficacy and safety of OACs in Japanese cancer patients with AF. We sought to investigate the efficacy and safety of OACs in this population. Methods This retrospective cohort study included active cancer patients in whom AF was recorded by electrocardiography in our hospital from January 2014 to December 2016 and who were treated with DOACs or warfarin. Patients were followed for 1 year. The study outcomes were stroke or systemic embolism and major bleeding. Result A total of 224 patients with AF and active cancer were treated with OACs (DOACs, n=127; warfarin, n=97). Overall, stroke or systemic embolism and major bleeding occurred in seven (3.8%/year) and eight (4.9%/year) patients, respectively. Stroke or systemic embolism occurred in three patients in the DOAC group (2.8%/year) and four patients in the warfarin group (5.4%/year). Major bleeding occurred in four patients in the DOAC group (4.0%/year) and four ...Continue Reading

References

Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanna MasciArmando Santoro
Jul 11, 2003·The New England Journal of Medicine·Rodger L Bick
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ross CamidgeDuncan Jodrell
Apr 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinya SuzukiLong-Tai Fu
Jul 31, 2007·Journal of the American College of Cardiology·Albert Yuh-Jer ShenWansu Chen
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Apr 22, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Yugo YamashitaMasaharu Akao
May 28, 2017·The American Journal of Cardiology·Eva S LaubeSimon Mantha
Dec 13, 2017·The New England Journal of Medicine·Gary E RaskobUNKNOWN Hokusai VTE Cancer Investigators
May 11, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Annie M YoungMark Levine
Aug 7, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuo OkumuraUNKNOWN SAKURA AF Registry Investigators

❮ Previous
Next ❯

Citations

Oct 13, 2020·Journal of Thrombosis and Thrombolysis·Marco Valerio MarianiCarlo Lavalle
Dec 3, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Takanori IkedaHiroshi Inoue

❮ Previous
Next ❯

Software Mentioned

JMP

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.