[Oral anticoagulation and risk of bleeding in elderly patients - the aspect of polypharmacy].

Wiener medizinische Wochenschrift
Regina E RollerMarkus Gosch

Abstract

Oral anticoagulant therapy has been shown to be of benefit also in elderly patients in various therapeutic and prophylactic indications. Despite strong evidence in literature, doctors still refuse to prescribe oral anticoagulants to geriatric patients in daily routine. Main reason for this decision is the fear of secondary bleeding complications. According to clinical trial data, distinct risk factors for bleeding attributed to anticoagulant treatment may be determined: age >70 years, female gender, recurrent bleeding events, alcohol/drug abuse, diabetes, anaemia and polypharmacy. The entire article reveals the literature in Medline and Cochrane Library from 1980 to 2009 including the hits "polypharmacy - anticoagulant treatment - elderly patients". It further highlights risk assessment strategies in elderly patients, and possible pharmacokinetic and -dynamic interactions of drugs co-administered with oral anticoagulants.

References

Mar 13, 1999·Archives of Internal Medicine·P M KuijerH R Büller
Mar 1, 2000·Archives of Internal Medicine·G PalaretiS Coccheri
Feb 7, 2001·Chest·M N LevineC Kearon
Mar 29, 2001·Clinics in Geriatric Medicine·E M Hylek
Jan 14, 2004·Archives of Internal Medicine·Margaret C FangDaniel E Singer
Oct 13, 2004·Archives of Internal Medicine·Nadya KaganskyShmuel Levy
Jan 14, 2005·Journal of Clinical Pharmacology·David J Greenblatt, Lisa L von Moltke
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Aug 22, 2006·Alimentary Pharmacology & Therapeutics·L LaineR W Dubois
Nov 14, 2006·Chest·Theresa I ShiremanEdward F Ellerbeck

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Citations

Sep 5, 2013·Wiener medizinische Wochenschrift·Heinrich Wolfgang ThalerMarkus Gosch
Jan 13, 2015·Clinical Pharmacokinetics·Charles E FrostFrank LaCreta
Mar 24, 2012·Zeitschrift für Gerontologie und Geriatrie·R E Roller, P Feichtinger

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