Oral antihistamine-decongestant-analgesic combinations for the common cold

The Cochrane Database of Systematic Reviews
An I M De SutterAlja Skrt

Abstract

Although combination formulas containing antihistamines, decongestants and/or analgesics are sold over-the-counter (OTC) in large quantities for the common cold, the evidence of effectiveness is limited. To assess the effectiveness of antihistamine-decongestant-analgesic combinations in reducing the duration and alleviating the symptoms of the common cold in adults and children. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4), which contains the Cochrane Acute Respiratory Infections Group's Specialised Register, OLDMEDLINE (1953 to 1965), MEDLINE (1966 to November Week 3, 2011) and EMBASE (1990 to December 2011). Randomised controlled trials (RCTs) investigating the effectiveness of antihistamine-decongestant-analgesic combinations compared with placebo, other active treatment (excluding antibiotics) or no treatment in children and adults with the common cold. Two review authors independently extracted and summarised data on general recovery, nasal obstruction, rhinorrhoea, sneezing, cough and side effects. We categorised the trials according to the active ingredients. We included 27 trials (5117 participants) of common cold treatments. Fourteen trials studied antihi...Continue Reading

References

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Citations

Nov 14, 2013·Respiratory Research·Martin LudwigChristian A Mueller
Dec 20, 2014·International Journal of Pediatrics·Mohd Masnoon SaiyedDevang Rana
Apr 23, 2014·Indian Journal of Pediatrics·Keya Rani Lahiri, Amruta Avinash Landge
Oct 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Anika ThielmannBirgitta Weltermann
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Laura DeckxMieke L van Driel
Jul 3, 2013·The Cochrane Database of Systematic Reviews·Siyuan LiTaixiang Wu
Oct 28, 2014·The Cochrane Database of Systematic Reviews·Nader Shaikh, Ellen R Wald
Nov 29, 2015·The Cochrane Database of Systematic Reviews·An Im De SutterMieke L van Driel
Nov 26, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Neil FodenRobert Almeyda
Mar 18, 2016·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Julie DeGrootUNKNOWN TARGet Kids! collaboration
Oct 12, 2018·BMJ : British Medical Journal·Mieke L van DrielAn De Sutter
Aug 30, 2017·The Cochrane Database of Systematic Reviews·Meenu SinghAnil Chauhan
Mar 13, 2014·The Cochrane Database of Systematic Reviews·Christina C ChangAnne B Chang
Jun 5, 2020·Current Allergy and Asthma Reports·Francesca JaumeJoaquim Mullol
Sep 3, 2017·Journal of Medical Internet Research·Michele P DysonLisa Hartling

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