PMID: 2478Dec 9, 1975

Oral antipyretic therapy: evaluation of benorylate, an ester of acetylsalicylic acid and paracetamol

European Journal of Pediatrics
S SimiläK Kouvalainen


The capacity of benorylate, an ester of acetylsalicylic acid and paracetamol, to reduce fever in children was compared with that of the components as such or as a combination. The series of cases studied consisted of 66 patients between the ages of 4 months and 12 years with rectal temperatures above 38.5 degrees C. Temperatures were recorded at 15 and 20 min and 1, 2, 4 and 6 hrs after the administration of the drug. The antipyretic effect of combined acetylsalicylic acid (11 mg/kg) and paracetamol (14 mg/kg) was superior to the effect of benorylate with a dose of 25 mg/kg and even of 50 mg/kg as well as better than the effect of either drug alone. Acetylsalicylic acid (10 mg/kg) and paracetamol (12.5 mg/kg) alone produced a significantly greater antipyretic effect than benorylate with a dose of 25 mg/kg. Given in a dose of 35--40 mg/kg, benorylate seems to have a significant antipyretic effect. However, this effect is clearly smaller than that of either of its components, acetylsalicylic acid or paracetamol. Therefore benorylate is probably not suitable to be used as a general antipyretic agent in children.


May 27, 1972·British Medical Journal·D L BealesR Grahame
Apr 1, 1973·Archives of Disease in Childhood·J Hunter
Jul 1, 1972·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A RobertsonA K Watson
Jan 26, 1974·British Medical Journal·R H Powell, B M Ansell
Mar 1, 1972·American Journal of Diseases of Children·R W SteeleH C Shirkey
May 1, 1957·The Journal of Pediatrics·M T COLGAN, A A MINTZ
Mar 1, 1960·The Journal of Pediatrics·J G MILLICHAPJ A MADSEN


Jun 1, 1994·European Journal of Pediatrics·D Adam, G Stankov
Oct 6, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jonathon M BrownMonica S Vavilala
Oct 24, 2020·Scientifica·Murad N AbualhasanNael S Abu-Hasan

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