Jul 14, 2005

Oral bacteria in the occluded arteries of patients with Buerger disease

Journal of Vascular Surgery
T IwaiI Ishikawa

Abstract

Recent studies have suggested that infectious organisms play a role in vascular diseases. In this study, to explore a possible link between oral infection and Buerger disease, we investigated whether oral (periodontal) bacteria were present in occluded arteries removed from patients with characteristic Buerger disease. Fourteen male patients with a smoking history who had developed characteristics of Buerger disease before the age of 50 years were included in this study. Occluded arteries, including superficial femoral (n = 4), popliteal (n = 2), anterior tibial (n = 4), and posterior tibial (n = 4) arteries, were removed and studied. A periodontist performed a periodontal examination on each patient and collected dental plaque and saliva samples from them at the same time. The polymerase chain reaction method was applied to detect whether seven species of periodontal bacteria--Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Campylobacter rectus, Actinobacillus actinomycetemcomitans, Prevotella intermedia , and Prevotella nigrescens--were present in the occluded arteries and oral samples. In addition, arterial specimens from seven control patients were examined by polymerase chain reaction analysis. DNA ...Continue Reading

  • References23
  • Citations69

Mentioned in this Paper

Prevotella nigrescens
Microorganism
Arterial System
Giant Cells
Immune System Diseases
Treponema pallidum (bacteria)
Saliva - SpecimenType
Polymerase Chain Reaction Analysis
Campylobacter rectus
Dental Plaque

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