Oral bacterial flora and oral cancer: The possible link?

Journal of Oral and Maxillofacial Pathology : JOMFP
Pratyusha Prakash GaonkarGokul Sridharan

Abstract

Oral cancer exhibits multifactorial etiology with tobacco and alcohol long been implicated as the primary risk factors. In addition, betel nut, dietary factors and poor oral hygiene have also been found to have a role in the etiology of oral cancer. Past research has uncovered a great deal of information regarding the association of exogenous bacteria with cancer. However, our definitive knowledge of the oral commensal bacteria and oral cancer link remains inadequate. In the present article, we hypothesize a causal role for oral bacterial flora in oral cancer although an indirect one. We propose that the normal bacterial flora in conjunction with the already established risk factors such as alcohol consumption may play a role in cancer development. The continued exploration of this topic may aid in better understanding of the pathogenesis of oral cancer thereby helping in appropriate treatment and better prognosis.

References

Jan 1, 2010·Journal of Oral Microbiology·Jukka H Meurman

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Citations

Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paula SilvaGiovanni de Gaetano
Sep 24, 2020·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Nayara Fernanda PereiraMaria Gabriela Haye Biazevic
Jan 24, 2019·Journal of Oral Microbiology·Ingar Olsen, Özlem Yilmaz
Aug 3, 2019·Technology in Cancer Research & Treatment·Indranil ChattopadhyayMadhusmita Panda
Jan 3, 2021·Clinical Oral Investigations·Fernanda MonedeiroBogusław Buszewski
Dec 11, 2020·International Journal of Molecular Sciences·Totan AlexandraGreabu Maria
Mar 30, 2021·Computational and Structural Biotechnology Journal·Allan Radaic, Yvonne L Kapila
Apr 12, 2021·Biochimica Et Biophysica Acta. Proteins and Proteomics·Daniela C GranatoAdriana F Paes Leme
Nov 12, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Heidi Tuominen, Jaana Rautava

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Methods Mentioned

BETA
chromosomal aberrations

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