Oral beclomethasone dipropionate as an alternative to systemic steroids in mild to moderate ulcerative colitis not responding to aminosalicylates.

Digestive Diseases and Sciences
C PapiLucio Capurso

Abstract

Aminosalicylates (5-ASA) are first-line treatment for mild-moderate ulcerative colitis (UC). Systemic corticosteroids (CS) are considered for patients in whom 5-ASA has been unsuccessful, but their use is limited by adverse effects. Beclomethasone dipropionate (BDP), a topically acting steroid with low systemic bioavailability, has a more favorable safety profile, but its role in clinical practice is not yet well established. The aim of the present study is to assess whether oral BDP can be an alternative treatment to systemic CS for patients with mild-moderate UC not responding to first-line therapy with 5-ASA. From 2003 to 2006, all consecutive patients with mild-moderate UC unresponsive to oral and topical 5-ASA (+/-topical CS) administered for at least 3 weeks received an 8-week course of oral BDP (10 mg/day for 4 weeks and 5 mg/day for an additional 4 weeks). Co-primary end-points were: (1) clinical remission within 8 weeks, without need of systemic CS; (2) steroid-free remission for 12 months. Sixty-four patients were included. In this study, within 8 weeks, 48/64 patients (75%) entered remission without systemic CS, while 16/64 (25%) failed to enter remission. Within 12 months, 37/64 patients (58%) had prolonged steroid-...Continue Reading

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Dec 3, 2010·Journal of Crohn's & Colitis·Tiago NunesUNKNOWN RECLICU Study Group of GETECCU
Apr 8, 2014·World Journal of Gastroenterology : WJG·Giovanni MaconiRoberto de Franchis
Jul 13, 2012·Journal of Crohn's & Colitis·Tiago NunesMiquel Sans
Jan 8, 2014·Journal of Crohn's & Colitis·Paolo GionchettiFernando Rizzello
Jun 3, 2014·Expert Review of Gastroenterology & Hepatology·Simone SaibeniFederica Fascì-Spurio
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Nov 9, 2019·United European Gastroenterology Journal·Thomas De CorteFilip Baert

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