Oral Bioavailability, Hydrolysis, and Comparative Toxicokinetics of 3-Acetyldeoxynivalenol and 15-Acetyldeoxynivalenol in Broiler Chickens and Pigs

Journal of Agricultural and Food Chemistry
Nathan BroekaertSiska Croubels

Abstract

The goal of this study was to determine the absolute oral bioavailability, (presystemic) hydrolysis and toxicokinetic characteristics of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol in broiler chickens and pigs. Crossover animal trials were performed with intravenous and oral administration of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol to broilers and pigs. Plasma concentrations were analyzed by using liquid chromatography-tandem mass spectrometry, and data were processed via a tailor-made compartmental toxicokinetic analysis. The results in broiler chickens showed that the absorbed fraction after oral deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol administration was 10.6, 18.2, and 42.2%, respectively. This fraction was completely hydrolyzed presystemically for 3-acetyldeoxynivalenol to deoxynivalenol and to a lesser extent (75.4%) for 15-acetyldeoxynivalenol. In pigs, the absorbed fractions were 100% for deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol, and both 3-acetyldeoxynivalenol and 15-acetyldeoxynivalenol were completely hydrolyzed presystemically. The disposition properties of 3-acetyldeoxynivalenol and 15-acetyldeoxynivalenol demo...Continue Reading

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Citations

Jun 14, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Denis MaleFelicia Wu
Jun 25, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nathan BroekaertSiska Croubels
Sep 25, 2016·Archives of Toxicology·Delphine PayrosIsabelle P Oswald
May 19, 2017·Journal of Agricultural and Food Chemistry·Nathan BroekaertSiska Croubels
Oct 23, 2019·Frontiers in Microbiology·Dipendra K MahatoSang G Kang
Oct 7, 2017·The Veterinary Record·Tommy Van LimbergenDominiek Maes
Sep 11, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Lutz Edler
Apr 21, 2020·Toxicology Mechanisms and Methods·Mercedes TaroncherMaria-Jose Ruiz
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Hongyan GuoXiulan Sun
Feb 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wim SchelstraeteSiska Croubels
Aug 27, 2021·Toxins·Agnieszka Tkaczyk, Piotr Jedziniak

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