Oral Bisphenol-A Regulates The Development and Function of Reproductive System through Differential Expression of METTL3

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Zhe ZhangGuijun Yan

Abstract

Endocrine-disrupting chemicals (EDCs), which have a profound impact on the reproductive system, can cause endocrine and reproductive disorders, such as polycystic ovary syndrome (PCOS). Bisphenol-A (BPA) is a common endocrine disruptor which can affect the function of the reproductive system. However, the mechanism by which this molecule disrupts normal reproduction is still unclear. In this study, we hypothesized that oral BPA would have a effect on the structure and function of the reproductive system in adolescent female rats, and we would explore a kind of feasible mechanism for this effect. 4-week-old Sprague-Dawley (SD) rats were intragastrically treated for 10 weeks, which were divided into blank group (n = 8), control group (soybean oil, n = 8), three BPA-treatment groups (0.5 mg/kg BPA + soybean oil, 5 mg/kg BPA + soybean oil, 50 mg/kg BPA + soybean oil, n = 8). The results showed that 0.5 mg/kg oral BPA increased the coefficient of uteri, and oral BPA increased the length of uteri in rats without causing hyperandrogenism and ovarian polycystic changes. Oral BPA disturbed the expression of CYP17A1, CYP11A1 and METTL3 in ovaries. Our results suggested that oral BPA might partially interfere uterine morphology and the le...Continue Reading

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