PMID: 8977343Aug 1, 1996Paper

Oral calcium tolerance test in the early diagnosis of primary hyperparathyroidism and multiple endocrine neoplasia type 1 in patients with the Zollinger-Ellison syndrome. Groupe de Recherche et d'Etude du Syndrome de Zollinger-Ellison

Gut
G CadiotM Mignon

Abstract

In patients with the Zollinger-Ellison syndrome, the exclusion of multiple endocrine neoplasia type 1 is of important clinical relevance. Its diagnosis often relies on the existence of primary hyperparathyroidism. To investigate the parathyroid function of patients with the Zollinger-Ellison syndrome by use of an oral calcium tolerance test to identify both hypercalcaemic and normocalcaemic primary hyperparathyroidism, and, accordingly, multiple endocrine neoplasia type 1. Among 51 consecutive patients with the Zollinger-Ellison syndrome referred to us between 1988 and 1994, 28 had not been investigated for parathyroid function and were prospectively studied. The investigation of calcium metabolism was abnormal in nine patients. One displayed characteristic features of humoral hypercalcaemia of malignancy. The diagnosis of primary hyperparathyroidism was biologically established in eight patients (29%) and subsequently confirmed by the presence of hyperplasia of the parathyroid glands in the seven patients who underwent neck exploration. Three patients with primary hyperparathyroidism had fasting hyper-calcaemia but the other five had normal fasting serum total calcium concentration and the diagnosis of primary hyperparathyroid...Continue Reading

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Citations

Jun 1, 1995·Digestive Diseases and Sciences·G CadiotM Mignon
Jul 23, 2002·The American Journal of Medicine·Nicolas LerolleEric Rondeau
Oct 3, 2002·Surgical Oncology·Matthew J Glascock, Sally E Carty
Apr 11, 2001·Trends in Endocrinology and Metabolism : TEM·D H SchussheimS J Marx
Jan 21, 2012·Neuroendocrinology·Robert T JensenUNKNOWN Barcelona Consensus Conference participants
Dec 1, 2012·La Revue de médecine interne·G MaruaniP Houillier
Apr 18, 2015·Annales d'endocrinologie·Jean-Claude SouberbielleCatherine Cormier
Aug 14, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Ozlem EngizMerih Berberoglu
Mar 15, 2005·Annals of Dyslexia·Séverine CasalisDelphine Sopo
Apr 26, 2013·The Journal of Pathology·Katayoon KasaianSteven J M Jones
Sep 14, 2013·Arquivos brasileiros de endocrinologia e metabologia·UNKNOWN Sociedade Brasileira de Endocrinologia e MetabologiaJohn Bilezikian
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·S U GoebelJ Serrano
Jul 5, 2003·Journal of Endocrinological Investigation·P HagagM Weiss
Jan 26, 2020·Journal of Clinical Medicine·Elsa DenoixJean-Benoît Arlet

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