Oral candidiasis in patients receiving radiation therapy for head and neck cancer

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Zeyi DengMikio Suzuki

Abstract

To investigate oral candidiasis in patients with head and neck cancer before, during, and after radiation therapy, and to explore its association with clinical oropharyngeal symptoms. A cohort study. University hospital. Subjects who received radiation therapy (RT) for the treatment of head and neck cancer were divided into two groups: an oral cavity irradiated group (OIRR group, n = 29) and an oral cavity nonirradiated group (ONIRR group, n = 17). A control group consisted of 18 healthy subjects. Patients were examined for signs of oral candidiasis before, during, immediately after, and one month after RT. Mouth and throat soreness (MTS), dysphagia, and xerostomia were evaluated by self-reported questionnaires, and associations between oral candidiasis and these symptoms were analyzed. The incidence of oral candidiasis during RT was significantly higher in the OIRR group (55.2%) than in the ONIRR group (11.8%). Similarly, the occurrence of xerostomia during RT was significantly higher in the OIRR group (86.2%) than in the ONIRR group (52.9%). In the OIRR group, the mean MTS score at the 20th fraction of RT was significantly higher in patients with candidiasis (mean +/- SD, 5.8 +/- 2.1) than in those with RT-induced mucositis w...Continue Reading

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Citations

Sep 11, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ana MañasUNKNOWN Grupo de Investigación Clínica en Oncología Radioterápica (GICOR)
Oct 7, 2011·Expert Review of Anti-infective Therapy·Mustafa Hacimustafaoglu, Solmaz Celebi
Feb 8, 2011·Microbial Pathogenesis·Nishant P YadevMartin H Thornhill
Feb 1, 2015·Seminars in Oncology Nursing·Victor SierpinaMoshe Frenkel
Dec 15, 2010·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Richard Simcock, Valerie Jenkins

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