Oral carriage of Candida species in children and adolescents with Down's syndrome

International Journal of Paediatric Dentistry
K CarlstedtT Modéer

Abstract

Oral carriage of Candida albicans was studied in 55 children and adolescents with Down's syndrome (DS), aged between 7 months and 20 years 6 months, and compared with an age- and sex-matched control group of subjects. Twenty-two of the DS subjects were diagnosed as having congenital cardiovascular malformations. Compared to controls, the DS subjects were more prone to infections. The number of subjects colonized with C. albicans in the oral cavity was significantly higher in the DS group (69%) than in the control group (35%). Colonization with C. albicans and simultaneous erythematous or white pseudomembranous lesions of the oral mucosa were diagnosed in 22 (40%) of the DS groups and in only one of the control group. In both the DS and the healthy control subjects the frequency of colonization with C. albicans was positively correlated to age. The DS subjects were significantly more densely colonized by C. albicans than the controls. Abnormalities of the immune response in DS children may contribute to the increased oral carriage of C. albicans.

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Citations

Sep 21, 2005·Revista Da Sociedade Brasileira De Medicina Tropical·José Daniel Gonçalves VieiraJuliana de Sousa dos Santos
Jan 12, 2001·Oral Microbiology and Immunology·E C SheehyG J Roberts
Jul 9, 2002·The British Journal of Dermatology·C ScullyM-F Davison
Aug 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Flavia A LimaMagda Carneiro-Sampaio
May 28, 2020·Mycopathologia·Fernanda Cristina de Albuquerque MaranhãoDenise Maria Wanderlei Silva

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