Oral cGVHD screening tests in the diagnosis of systemic chronic graft-versus-host disease

Clinical Oral Investigations
Renata Gonçalves ResendeMauro Henrique Nogueira Guimarães Abreu

Abstract

To determine the diagnostic properties of oral manifestations and histological features of graft-versus-host disease (GVHD) screening tests in the diagnosis of systemic chronic graft-versus-host disease (cGVHD). Sixty patients having undergone allogeneic haematopoietic stem cell transplantation were selected. The patients were submitted to a clinical oral examination to assess symptoms and clinical changes in the oral mucosa. Histopathologic analysis of the lower lip oral mucosa (LLOM) and salivary glands (SG) was also performed. Systemic cGVHD was used for a comparison to oral cGVHD. The accuracy of oral cGVHD tests was low for all methods (58.4% and 52.6% for white lesions and white/red lesions, respectively, in the clinical analysis; 50.4% for the presence of oral pain; and 66.8% and 55.1% for LLOM and SG histopathologic tests, respectively). However, the presence of oral pain had good diagnostic properties [specificity: 100.0, 95% confidence interval (CI): 88.0-100.0; positive predictive value (PPV): 100.0, 95% CI: 94.4-100.0; and negative predictive value (NPV): 72.0, 95% CI: 57.3-83.3]. Moreover, SG alterations revealed by the histopathological analysis also exhibited good diagnostic properties (sensitivity: 98.6, 95% CI:...Continue Reading

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Citations

Jul 17, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Wanninayake M TilakaratneHemantha Amarasinghe

Related Concepts

Esophageal Dysphagia
Erythema
Orofacial Pain
Graft-vs-Host Disease
Immunosuppressive Agents
Lip Diseases
Mouth Diseases
Buccal Mucosa
Salivary Gland Diseases
Minor Salivary Gland Structure

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