Oral cholera vaccination promotes homing of IgA+ memory B cells to the large intestine and the respiratory tract

Mucosal Immunology
M van SplunterR J J van Neerven

Abstract

Oral cholera vaccination is used to induce immune responses in the intestines to protect against cholera infection. However, oral vaccination may also affect immune responses in other mucosal tissues. To study this, tissue-specific homing potential and kinetics of B-cell responses were characterized after oral cholera vaccination. Healthy adult volunteers received two doses of Dukoral® and blood, saliva, nasal wash, and fecal samples were collected over time to detect vaccine-specific antibodies. Additionally, homing potential of lymphocytes to small intestine, colon, airways, skin, and periphery was measured by expression of Integrin β1 and β7, CCR9, CCR10, CCR7, and CLA. After vaccination, antibody responses to cholera toxin B (CTB) and Dukoral® were detected in serum and nasal wash. CTB-specific memory B cells in peripheral blood and tissue homing profiles of memory B cells peaked at day 18. IgA+ memory B cells expressed markers that enable homing to the airways and colon, while IgA- memory B cells primarily expressed small-intestine-homing markers. These data show that oral cholera vaccination has a differential effect on immune responses in various mucosal sites, including the respiratory tract.

References

Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·J MoralesA Zlotnik
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J PanD Soler
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Feb 5, 2002·Immunity·Eric J Kunkel, Eugene C Butcher
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jen-Tsan ChiPatrick O Brown
Jul 29, 2005·Immunological Reviews·Per Brandtzaeg, Finn-Eirik Johansen
Feb 24, 2006·Nature Reviews. Immunology·Marian R Neutra, Pamela A Kozlowski
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuki HiraharaThomas S Kupper
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aiko-Konno ShirakawaOsamu Yoshie
Jun 6, 2008·Vaccine·Ian Francis Cook
Oct 15, 2008·The Journal of Experimental Medicine·Swantje I HammerschmidtOliver Pabst
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Igor M Belyakov, Jeffrey D Ahlers
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Per Brandtzaeg
Jul 9, 2011·The Journal of Clinical Investigation·Swantje I HammerschmidtReinhold Förster
Apr 11, 2012·Inflammatory Bowel Diseases·Nicole J TarltonTzvia Abramson
May 15, 2012·Current Opinion in Immunology·Jan Holmgren, Ann-Mari Svennerholm
Oct 12, 2013·Frontiers in Immunology·Bas J G BaatenLinda M Bradley
Jun 12, 2014·Mucosal Immunology·E DanilovaE S Baekkevold
Nov 26, 2014·Nature Reviews. Immunology·Benjamin J Marsland, Eva S Gollwitzer
Jan 13, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sabra L KleinEleanor N Fish
Jan 24, 2015·Science·Mathias UhlénFredrik Pontén
Jan 30, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Atul SrivastavaMeenakshi Iyer
May 9, 2015·Expert Opinion on Drug Delivery·Yimei JiaAbdelwahab Omri
Oct 27, 2015·Frontiers in Microbiology·Derrick R SamuelsonJudd E Shellito
Feb 14, 2016·Journal of the Egyptian National Cancer Institute·Azza M KamelEman Z Kandeel
Nov 3, 2016·Current Opinion in Pediatrics·Magali Noval RivasMoshe Arditi
Nov 1, 2016·Nature Reviews. Microbiology·Kurtis F BuddenPhilip M Hansbro

❮ Previous
Next ❯

Citations

Jul 31, 2019·The Journal of Clinical Investigation·Simon P JochemsDaniela M Ferreira
Jun 6, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Maria Lucía Orsini DelgadoGuillermo Horacio Docena
Dec 11, 2019·Antibodies·Patrícia de Sousa-Pereira, Jenny M Woof
Apr 1, 2020·Expert Review of Vaccines·Gerco den HartogFiona R M van der Klis
Jun 12, 2020·Cell Host & Microbe·Meera K Shenoy, Meghan A Koch
Jul 28, 2021·Nature Reviews. Immunology·Ed C Lavelle, Ross W Ward
Aug 20, 2021·Advanced Drug Delivery Reviews·Yuandong ZhangXun Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
FACS
enzyme-linked immunosorbent assay
ELISA
ELISAs

Clinical Trials Mentioned

NCT02238548

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2022 Meta ULC. All rights reserved