Oral clonidine premedication reduces vomiting in children after strabismus surgery

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
K MikawaH Obara

Abstract

This is a prospective randomized double-blind trial conducted to determine whether preoperative orally administered clonidine causes or potentiates postoperative vomiting in 140 children (3-12 yr) undergoing strabismus surgery. They were all inpatients and classified randomly into four groups (n = 35 each); placebo (control), diazepam 0.4 mg.kg-1, clonidine 2 micrograms.kg-1, and clonidine 4 micrograms.kg-1. These agents were administered 93-112 min (mean; 100 min) before the anticipated time of induction of anaesthesia. All children received inhalational anaesthesia with halothane and nitrous oxide in oxygen. Muscle relaxation in all patients was obtained with vecuronium and residual neuromuscular blockade was antagonized with neostigmine and atropine before tracheal extubation. Diclofenac suppository was prescribed to prevent postoperative pain. No opioids or postoperative antiemetics were administered. All children remained in hospital for two days postoperatively. The incidence and frequency of vomiting were compared in the groups with Kruskall-Wallis Rank test. Clonidine 4 micrograms.kg-1 caused a lower incidence and frequency of vomiting than did placebo and diazepam (incidence and frequency: 11% and 1.37% and 3, and 34% ...Continue Reading

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Citations

Mar 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E J ReimerP M Merrick
Jan 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K MikawaH Obara
Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ashraf S Habib, Tong J Gan
Dec 15, 2000·Neuropharmacology·A RobichaudC C Chan
Apr 23, 2002·Alimentary Pharmacology & Therapeutics·V HuilgolK H Soergel
May 13, 1999·Paediatric Anaesthesia·K NishinaH Obara
Jul 8, 2003·American Journal of Therapeutics·Tariq A KhasawinahJoseph D Tobias
Mar 1, 1997·Acta Anaesthesiologica Scandinavica·H T BergendahlP A Lönnqvist
May 23, 1998·Acta Anaesthesiologica Scandinavica·G IvaniP A Lönnqvist
Jan 15, 2005·Paediatric Anaesthesia·Greta M Palmer, Donald J S Cameron
Jul 21, 2011·Journal of Anaesthesiology, Clinical Pharmacology·Usha ShuklaKiran Malhotra
Mar 8, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Shiv Kumar RaghuwanshiVishal Bankwar
Feb 15, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Farnoosh MohammadiOveis Khakbaz
Dec 6, 2005·The Surgical Clinics of North America·Karen Stanley Williams
May 30, 2014·Advanced Drug Delivery Reviews·Vincent JanninCatherine Tuleu
Dec 30, 2016·The Journal of Pharmacy and Pharmacology·Sara M HanningUNKNOWN CloSed Consortium
Jun 19, 2003·Anesthesiology Clinics of North America·Martin RedmondPeter S A Glass
May 1, 2002·Anesthesiology·Eva Oddby-MuhrbeckPer Arne Lönnqvist
Jan 29, 2014·The Cochrane Database of Systematic Reviews·Paul LambertPhilippa Middleton
Jul 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Mary Binsu Abraham, Paul Porter
Jan 21, 2010·Acta Anaesthesiologica Scandinavica·S DahmaniI Murat
Jul 3, 2015·The Cochrane Database of Systematic Reviews·Joseph F StandingMarina Waddington
Apr 11, 2000·Acta Anaesthesiologica Scandinavica·G IvaniP A Lönnqvist
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson
May 29, 2002·Anesthesia and Analgesia·Katsuya MikawaMakoto Shiga
Apr 8, 2014·The Journal of Craniofacial Surgery·Reza TabriziMohammad Saleh Khaghaninejad

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