PMID: 9649913Jul 3, 1998Paper

Oral contraception and other factors in relation to hospital referral for fracture. Findings in a large cohort study

Contraception
M P VesseyR Painter

Abstract

There is good evidence that estrogens and progestogens have an important effect on bone metabolism. This article explores the relationship between oral contraceptive (OC) use and fractures occurring at various sites among the 17,032 participants in the Oxford-Family Planning Association contraceptive study, which now includes information accumulated during 310,000 woman-years of observation between 1968 and 1994. In total, 1308 women suffered at least one fracture during the follow-up period, which was largely confined to premenopausal years. When all fractures were combined, there was a modest, but highly significant trend (p < 0.001) of increasing risk with total duration of oral contraceptive use. In addition, there was statistically significant heterogeneity (p < 0.01) when overall fracture rates were examined in relation to recency of oral contraceptive use during the premenopausal lifespan. The highest relative risk (1.3, 95% CI 1.1-1.5) was for current or recent oral contraceptive users; however, viewed as a whole, no clear pattern of risk was apparent. Examination of the data for individual fracture sites (including the lower end of the radius/ulna) did not provide any evidence of a protective effect of oral contracepti...Continue Reading

References

Feb 1, 1991·The American Journal of Medicine·J C GallagherD Goldgar

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Citations

Jun 22, 2001·Pharmacoepidemiology and Drug Safety·M Goldacre
Oct 20, 2001·Pharmacoepidemiology and Drug Safety
Feb 7, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Florence Trémollieres
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Sep 11, 2009·Clinical Endocrinology·Markus Herrmann, Markus J Seibel
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Oct 4, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Emily A Southmayd, Mary Jane De Souza
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Dec 16, 2021·Minerva Obstetrics and Gynecology·Morena L RoccaCostantino DI Carlo

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