Oral contraceptives and cyproterone acetate in female acne treatment

Dermatology : International Journal for Clinical and Investigative Dermatology
C BeylotM Beylot-Barry

Abstract

The sebaceous gland is a target of androgens, and hormonal influences play an important role in the multifactorial pathogenesis of acne. In both men and women, acne may be related to an excessive hypersensitivity of the sebaceous end organ to androgens. However, in women, the ovarian and adrenal production and the plasma transport of androgens may be implicated, particularly in late-onset or persistent acne or with associated hirsutism. Many reports have shown that females with acne frequently have abnormal levels of circulating androgens. Hormonal treatment is not usually the first line in female acne. But in relation to the possibilities, particularly the tetracyclines, this may be a choice when one prescribes a pill like Dianette to a young woman presenting a mild acne and who requests contraception. However, antiandrogen treatment is sometimes mandatory, especially in resistant acne in adult women and/or in female acne which is resistant or relapsing rapidly after treatment with Roaccutane and which is often related to hyperandrogenism. Finally, in severe prepubertal acne, the possible cause is an adrenal enzymatic block of which the only treatment is hormonal.

Citations

Dec 20, 2002·Clinics in Dermatology·Marcia Ramos-e-SilvaAna Libia Cardozo Pereira
Apr 1, 2000·Clinics in Dermatology·A D Katsambas, E Nicolaidou
Jul 31, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kinga K BorowiczStanisław J Czuczwar
Jan 25, 2005·American Journal of Clinical Dermatology·Willem A van Vloten, Vigfus Sigurdsson
Nov 11, 2010·American Journal of Clinical Dermatology·Marissa D NewmanAlan R Shalita
May 23, 2008·International Journal of Cosmetic Science·H E KnaggsO H Mills
Nov 9, 2007·International Journal of Dermatology·Hassan SeirafiSeyedeh Zahra Ghodsi
Jul 2, 2003·Journal of the American Academy of Dermatology·Harald GollnickUNKNOWN Global Alliance to Improve Outcomes in Acne
Oct 30, 2003·The Cochrane Database of Systematic Reviews·Z M Van der Spuy, P A le Roux
Mar 14, 2001·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·C Piérard-FranchimontG E Piérard

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