Oral contraceptives and hormone replacement therapy do not increase the incidence of arterial thrombosis in a nonhuman primate model

Arteriosclerosis, Thrombosis, and Vascular Biology
D A BellingerD E Bender

Abstract

Older oral contraceptive (OC) formulations containing high doses of potent synthetic estrogens and progestins are associated with increased risk of thrombosis. To examine the effects of current low-dose OC and hormone replacement therapy (HRT) regimens on arterial thrombosis, premenopausal and surgically postmenopausal cynomolgus monkeys were divided into four treatment groups. Premenopausal monkeys were given either no OCs or ethinyl estradiol and levonorgestrel as an OC at a dose equivalent to that currently given to women. Postmenopausal monkeys were given either no HRT or conjugated equine estrogens and medroxyprogesterone as an HRT at a dose equivalent to that currently given to women. The monkeys were fed an atherogenic diet containing these treatments for 27 to 30 months. At the end of this time, arterial thrombosis was evaluated with a standardized stenosis/injury procedure in the left carotid artery. Blood flow velocity was monitored for cyclic or permanent occlusive thrombosis. The current OC and HRT regimens did not increase the susceptibility of the artery wall to develop an occlusive thrombus following injury and stenosis. In fact, there was a reduction in the incidence of thrombosis in the OC animals compared with...Continue Reading

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Citations

Nov 15, 2002·International Journal of Hematology·Kwang Kon Koh
Jul 26, 2000·Obstetrics and Gynecology·M R AdamsJ S Parks
Oct 1, 2015·Case Reports in Medicine·Hyung-Il ChoiJu-Young Moon
Sep 29, 2001·British Journal of Anaesthesia·D Brighouse
Jul 20, 2004·Angiology·Rebecka HultgrenEric Wahlberg
Sep 21, 2000·Cephalalgia : an International Journal of Headache·S J Kittner, M G Bousser
Jan 23, 2003·The Journal of Pharmacology and Experimental Therapeutics·Claudia K DerianPatricia Andrade-Gordon
Dec 24, 2014·Journal of Medical Primatology·Sharon Dietz OstergaardEllen N Kersh
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·M A A J Van Den BoschY Van Der Graaf

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