Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial.

Frontiers in Pharmacology
Kirti S PawarAditi R Deshpande

Abstract

Background: Coronavirus disease-2019 (COVID-19) has a wide range of pathophysiological effects. Curcumin, an active constituent of Curcuma longa (turmeric), has several properties, including anti-inflammatory, antioxidant, antiviral, anti-thrombotic, and anti-proliferative effects, which make it a promising candidate for the symptomatic treatment of COVID-19. Objective: We aimed to determine the effects of curcumin administered with piperine (to optimize absorption) on symptoms in patients with COVID-19 in a double-blind, randomized, controlled trial at a 30-bed dedicated COVID Health Center (DCHC) in Maharashtra, India. Methods: In addition to conventional COVID-19 treatment, patients in the control group received a dose of probiotics twice a day, and patients in the study group received curcumin (525 mg) with piperine (2.5 mg) in tablet form twice a day. The effects of curcumin/piperine treatment on primary and secondary outcomes were assessed for the duration of hospitalization. Results: Patients with mild, moderate, and severe symptoms who received curcumin/piperine treatment showed early symptomatic recovery (fever, cough, sore throat, and breathlessness), less deterioration, fewer red flag signs, better ability to maintai...Continue Reading

References

Dec 21, 2006·Clinical and Experimental Immunology·S SharmaJ N Agrewala
Jun 16, 2007·Advances in Experimental Medicine and Biology·Narayanan VenkatesanMary Babu
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Mar 11, 2008·Molecular Nutrition & Food Research·Saibal Biswas, Irfan Rahman
Aug 2, 2008·Expert Review of Neurotherapeutics·Bruce Ovbiagele
Feb 24, 2009·International Journal of Cardiology·Wanwarang Wongcharoen, Arintaya Phrommintikul
Jul 11, 2009·The AAPS Journal·Jayaraj RavindranBharat B Aggarwal
May 29, 2010·Methods and Findings in Experimental and Clinical Pharmacology·V SharmaA Jyothy
Mar 26, 2011·Expert Opinion on Drug Metabolism & Toxicology·Hyo-Kyung Han
Apr 26, 2012·BMB Reports·Dong-Chan KimJong-Sup Bae
Nov 13, 2012·The AAPS Journal·Subash C GuptaBharat B Aggarwal
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Wei ZhangJun-Li Liu
Dec 5, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siddhartha S GhoshShobha Ghosh
Feb 11, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muthu K ShanmugamGautam Sethi
Aug 12, 2017·Critical Reviews in Food Science and Nutrition·Hamid MollazadehAmirhossein Sahebkar
Oct 21, 2017·Journal of Cellular Physiology·Faeze KeihanianAmirhossein Sahebkar
Oct 27, 2017·Foods·Susan J Hewlings, Douglas S Kalman
Dec 16, 2018·European Journal of Medicinal Chemistry·Bahare SalehiJavad Sharifi-Rad
Dec 1, 2017·Journal of Restorative Medicine·Shusuke Toden, Ajay Goel
May 21, 2020·Phytotherapy Research : PTR·Fatemeh ZahedipourAmirhossein Sahebkar
Aug 25, 2020·Indian Journal of Clinical Biochemistry : IJCB·Padmanaban S Suresh

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Citations

Jun 25, 2021·Chemico-biological Interactions·Sahar M Jaffal, Manal A Abbas
Sep 10, 2021·Phytotherapy Research : PTR·Aviral KumarAjaikumar B Kunnumakkara
Nov 2, 2021·The Journal of Microbiology·Erica EspañoJeong-Ki Kim
Nov 12, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Pooria AsiliBagher Larijani
Oct 21, 2021·Nutrition Research Reviews·Kamila Sabino BatistaJailane de Souza Aquino

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