Oral delivery of antigens in liposomes with some lipid compositions modulates oral tolerance to the antigens

Microbiology and Immunology
Kazuyoshi MasudaKoichiro Hirano

Abstract

Several liposomes containing ovalbumin (OVA), a model antigen, with different lipid compositions were prepared in order to evaluate their ability to induce oral tolerance. Oral administration of these liposomal OVAs induced suppression of the proliferative responses of popliteal lymph node cells from the treated mice to OVA, suggesting that these treated mice were tolerized. The efficiency of the induction of oral tolerance was affected by the liposome composition. OVA entrapment in these liposomes could modulate the tolerizing dose of OVA itself. These results suggest that some liposomes can be suitable antigen-delivery systems for modulated and/or effective induction of oral tolerance.

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Citations

Dec 13, 2006·Clinical & Developmental Immunology·Ana M C Faria, Howard L Weiner
Apr 23, 2010·Pharmaceutical Research·Gert FrickerChristel Müller-Goymann
Feb 3, 2005·Nature Reviews. Drug Discovery·Vladimir P Torchilin
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Oct 17, 2015·Nature Reviews. Drug Discovery·Natalie L TrevaskisChristopher J H Porter
Apr 2, 2003·Nature Reviews. Drug Discovery·Michael Goldberg, Isabel Gomez-Orellana
Jan 5, 2012·Journal of Microencapsulation·Dewi Melani HariyadiAllan G A Coombes
Jul 29, 2005·Immunological Reviews·Ana M C Faria, Howard L Weiner

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