Oral delivery of curcumin via porous polymeric nanoparticles for effective ulcerative colitis therapy

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Qiubing ChenDidier Merlin

Abstract

Oral drug delivery has been considered as a promising strategy for ulcerative colitis (UC) therapy. Here, an emulsion solvent evaporation technique was employed to prepare non-porous curcumin (CUR)-loaded polymeric nanoparticles (NPs) and porous CUR-loaded polymeric NPs in the absence or presence of ammonium bicarbonate. The resultant CUR-loaded NPs (non-porous NPs and porous NPs) had a desirable mean particle size of around 260 nm with a narrow size distribution, a uniform pore size distribution, slightly negative-charged surface, high encapsulation efficiency and controlled drug release capacity. In vitro experiments indicated that Raw 264.7 macrophages exhibited time-dependent accumulation profiles of NPs during the initial 2 h of co-incubation. Furthermore, we found that porous NPs inhibited the secretion of the main pro-inflammatory cytokines (TNF-α, IL-6 and IL-12) and the production of reactive oxygen species much more efficiently than non-porous NPs. Most importantly, in vivo studies demonstrated that oral administered porous NPs had a superior therapeutic efficiency in alleviating UC compared with non-porous NPs. The results collectively suggest that porous polymeric NPs can be exploited as efficient oral drug carriers...Continue Reading

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Citations

Mar 21, 2020·Current Topics in Medicinal Chemistry·Prasad MinakshiPreeti Lakhani
Mar 23, 2018·Critical Reviews in Food Science and Nutrition·Fernando Cunha NetoSandra Maria Barbalho
Jan 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Peng-Sheng FanYa Liu
Mar 13, 2021·International Journal of Pharmaceutics·Wenjuan LiuZhongjian Chen
Dec 31, 2018·International Journal of Pharmaceutics·Qiubing ChenBo Xiao
Apr 14, 2021·Artificial Cells, Nanomedicine, and Biotechnology·Susmita AryalJaehong Key

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