Oral delivery of natural compounds by phospholipid vesicles.

Nanomedicine
Maria ManconiAnna Maria Fadda

Abstract

The purpose of this report is to summarize and critically analyze emerging trends in phospholipid vesicles for the oral delivery of natural compounds. Liposomes have long been used as delivery systems, thanks to their ability to incorporate diverse bioactives, their biocompatibility and safety. However, the efficacy of oral liposomes is hampered by their low stability under the harsh conditions of the gastrointestinal tract. Different approaches have been utilized with the aim of improving the stability of liposomes and the payload after oral administration. This report provides an overview on the phospholipid vesicles used for oral delivery of natural compounds, exploring the current strategies to improve their performance by modifying the lipid bilayer composition and assembly or the physical state.

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Citations

May 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Apratim JashSyed S H Rizvi
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Syed Sarim ImamBjad K Almutairy

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Methods Mentioned

BETA
x-ray scattering
transmission
atomic
infrared spectroscopy

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