Oral delivery of replication-competent adenovirus vectors is well tolerated by SIV- and SHIV-infected rhesus macaques

Vaccine
V Raúl Gómez-RománMarjorie Robert-Guroff

Abstract

Although replication-competent adenovirus (Ad) vectors are promising in AIDS vaccine design, their safety in immune compromised hosts is unknown. To initially address this question, enteric-coated tablets containing a replicating Ad vector were orally administered to SHIV- and SIV-infected rhesus macaques with normal, intermediate or low CD4 T cell counts and stable disease. The vector was detected within a week after tablet administration in stools of all animals but not in nasal secretions, indicating no spread of virus to the upper respiratory tract. CD4 T cell counts and viral loads remained stable in all animals and no signs of fever, weight loss, or other clinical symptoms of Ad-induced disease were observed during 10 weeks of follow-up. Oral delivery of the replicating Ad vector was safe and well tolerated by SHIV- and SIV-infected hosts. Oral enteric-coated tablets may prove safe for administering replicating Ad-vectored vaccines in areas with high HIV prevalence.

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Citations

Mar 1, 2008·Expert Opinion on Therapeutic Patents·Tanu ChawlaSathyamangalam Swaminathan
Apr 6, 2007·Expert Review of Vaccines·Matthias LinigerHussein Y Naim
Aug 13, 2008·Expert Opinion on Biological Therapy·L Jean Patterson, Marjorie Robert-Guroff
Apr 23, 2008·Expert Opinion on Drug Delivery·Chun Wang, Phuong-Truc Pham
Jun 12, 2010·Biologicals : Journal of the International Association of Biological Standardization·J L ExclerW C Koff
May 28, 2013·Vaccine·Cailin DealGary Ketner
Oct 30, 2010·Immunity·Margaret A Liu
Jul 6, 2014·Virology·Catherine M Crosby, Michael A Barry
Dec 17, 2014·Vaccine·Lisanework E AyalewSuresh K Tikoo
Jul 6, 2014·Clinical and Vaccine Immunology : CVI·Michael G BergGary Ketner
Jan 17, 2020·FEBS Letters·Michael A BarryShao-Chia Lu
Dec 19, 2017·Expert Review of Vaccines·Michael Barry

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