PMID: 8996345Feb 1, 1997Paper

Oral desmopressin as a new treatment modality for primary nocturnal enuresis in adolescents and adults: a double-blind, randomized, multicenter study. Dutch Enuresis Study Group

The Journal of Urology
R A JanknegtH J Arendsen

Abstract

We evaluated the efficacy and safety of 2 oral doses of desmopressin compared to 20 micrograms. nasal spray and baseline values in the treatment of primary nocturnal enuresis. A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms. nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis. No significant differences were found between the 2 doses of desmopressin tablets or between the tablets and 20 micrograms. nasal spray during the double-blind phase. However, patients who initially received 200 micrograms. desmopressin tablets experienced fewer wet nights after they completed 12 weeks of open label treatment when the dose was escalated to 400 micrograms. tablets. Those who received 400 micrograms. tablets initially maintained response during this phase. Desmopressin tablets were well tolerated at both dose levels: 96% of patients and 94% of physicians rated the tolerability as excellent. Desmopressin tablets are an effective and safe alternative for treatment of nocturnal enuresis.

References

Nov 1, 1978·Acta paediatrica Scandinavica·T Tuvemo
Apr 1, 1989·The Journal of Pediatrics·J P NørgaardJ C Djurhuus
Jul 1, 1987·Archives of Disease in Childhood·A Fjellestad-PaulsenA S Harris
Jan 1, 1986·Archives of Disease in Childhood·S Wille
Mar 1, 1985·British Journal of Anaesthesia·E Cardan
Jul 1, 1985·Acta paediatrica Scandinavica·G Elinder, S Soback
Aug 1, 1984·British Journal of Urology·B G FerrieE S Glen
Oct 1, 1984·Australian and New Zealand Journal of Medicine·N W BoyceR C Atkins
Apr 1, 1984·Acta Endocrinologica·H Vilhardt, P Bie
Feb 1, 1982·Archives of Disease in Childhood·M AladjemS Freedman
Jun 1, 1982·British Journal of Urology·P D RamsdenJ D Bowditch
Dec 1, 1994·British Journal of Urology·S D EckfordP H Abrams

❮ Previous
Next ❯

Citations

Dec 4, 2002·BJU International·S NappoP Caione
Mar 17, 2004·Clinical Obstetrics and Gynecology·Ingrid E Nygaard, Karl J Kreder
Oct 9, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·E J Mikkelsen
Jan 8, 2009·International Journal of Clinical Practice·H LottmannJ P Norgaard
Aug 22, 2009·The Journal of Urology·Charlotte Van HerzeeleJohan Vande Walle
Oct 19, 2000·Journal of the American Geriatrics Society·M Miller
Jul 18, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·K E Andersson
Mar 23, 2017·Organic & Biomolecular Chemistry·Thilini D KondasingheJennifer L Stockdill
Feb 26, 1998·The Annals of Pharmacotherapy·E Ferreira, S R Letwin
Jul 26, 2002·The Cochrane Database of Systematic Reviews·C M Glazener, J H Evans
Nov 30, 2000·Scandinavian Journal of Urology and Nephrology·R J Butler, P Holland
Mar 10, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·T B West, T S Alster
Oct 14, 2006·Current Opinion in Urology·J L Bosch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.