Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation

Journal of Arrhythmia
Yoshizumi TakeiYoshiyuki Kijima

Abstract

We aimed to determine the effects of the oral direct renin inhibitor aliskiren on in vivo oxidative stress in atrial fibrillation (AF) patients. In this study, 150 mg oral direct renin inhibitor aliskiren was administered once daily to 12 permanent AF patients. Aliskiren significantly reduced urinary excretion of the oxidative stress biomarker 8-iso-prostglandin F2α and serum levels of matrix metalloproteinase-2(MMP-2). We concluded that aliskiren reduces in vivo oxidative stress and serum MMP-2 levels in patients with permanent AF.

References

Jun 30, 2007·Clinical Chemistry·Robert B NeumanSamuel C Dudley
Nov 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Megumi KunishigeTakeshi Hata
Jan 16, 2008·Journal of Cellular and Molecular Medicine·V PolyakovaS Kostin
Jul 12, 2008·Journal of the American College of Cardiology·Eleftherios M KallergisPanos E Vardas
Jun 30, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masayuki ShimanoToyoaki Murohara
May 18, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masanori AbeMasayoshi Soma

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